Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Transforming lymph nodes into tissue factories

Transplanting donor cells into lymph nodes regenerates liver, pancreas and thymus function in mice.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Generation of ectopic liver, pancreatic islets and thymus by lymph node transplantation.

Marina Corral

References

  1. Berthiaume, F., Maguire, T.J. & Yarmush, M.L. Annu. Rev. Chem. Biomol. Eng. 2, 403–430 (2011).

    Article  Google Scholar 

  2. Komori, et al. Nat. Biotechnol. 30, 976–983 (2012).

    Article  CAS  Google Scholar 

  3. Uygun, B.E. et al. Nat. Med. 16, 814–820 (2010).

    Article  CAS  Google Scholar 

  4. Rodewald, H.R. Curr. Top. Microbiol. Immunol. 251, 101–108 (2000).

    CAS  PubMed  Google Scholar 

  5. Gill, J., Malin, M., Holländer, G.A. & Boyd, R. Nat. Immunol. 3, 635–642 (2002).

    Article  CAS  Google Scholar 

  6. Seach, N. et al. Tissue Eng. Part C Methods 16, 543–551 (2010).

    Article  CAS  Google Scholar 

  7. Markert, M.L., Devlin, B.H. & McCarthy, E.A. Clin. Immunol. 135, 236–246 (2010).

    Article  CAS  Google Scholar 

  8. Poznansky, M.C. et al. Nat. Biotechnol. 18, 729–734 (2000).

    Article  CAS  Google Scholar 

  9. Clark, R.A., Yamanaka, K., Bai, M., Dowgiert, R. & Kupper, T.S. J. Clin. Invest. 115, 3239–3249 (2005).

    Article  CAS  Google Scholar 

  10. Hoppo, T., Komori, J., Manohar, R., Stolz, D.B. & Lagasse, E. Gastroenterology 140, 656–666 (2011).

    Article  CAS  Google Scholar 

  11. Terra, R. et al. Blood 106, 193–200 (2005).

    Article  CAS  Google Scholar 

  12. Maillard, I. et al. Blood 107, 3511–3519 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marcel R M van den Brink.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zakrzewski, J., Tuckett, A. & van den Brink, M. Transforming lymph nodes into tissue factories. Nat Biotechnol 30, 958–959 (2012). https://doi.org/10.1038/nbt.2388

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2388

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research