Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Modulating WNT receptor turnover for tissue repair

New mechanistic insight into the regulation of WNT signaling supports efforts to target this pathway in adult stem cells for regenerative medicine.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Modulating LGR5+ crypt stem cells with RSpo proteins for regeneration of the gastrointestinal epithelium.


  1. 1

    Hao, H.X. et al. Nature 485, 195–200 (2012).

    CAS  Article  Google Scholar 

  2. 2

    Minear, S. et al. Sci. Transl. Med. 2, 29–30 (2010).

    Article  Google Scholar 

  3. 3

    Diarra, D. et al. Nat. Med. 13, 156–163 (2007).

    CAS  Article  Google Scholar 

  4. 4

    Zhao, J. et al. Gastroenterology 132, 1331–1343 (2007).

    CAS  Article  Google Scholar 

  5. 5

    Zhao, J. et al. Proc. Natl. Acad. Sci. USA 106, 2331–2336 (2009).

    CAS  Article  Google Scholar 

  6. 6

    Krönke, G. et al. Arthritis Rheum. 62, 2303–2312 (2010).

    Article  Google Scholar 

  7. 7

    Sato, T. et al. Nature 459, 262–265 (2009).

    CAS  Article  Google Scholar 

  8. 8

    Barker, N. et al. Nature 449, 1003–1007 (2007).

    CAS  Article  Google Scholar 

  9. 9

    Carmon, K.S. et al. Proc. Natl. Acad. Sci. USA 108, 11452–11457 (2011).

    CAS  Article  Google Scholar 

  10. 10

    de Lau, W. et al. Nature 476, 293–297 (2011).

    CAS  Article  Google Scholar 

  11. 11

    Binnerts, M.E. et al. Proc. Natl. Acad. Sci. USA 104, 14700–14705 (2007).

    CAS  Article  Google Scholar 

  12. 12

    Mao, B. et al. Nature 417, 664–667 (2002).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding authors

Correspondence to Arie Abo or Hans Clevers.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Abo, A., Clevers, H. Modulating WNT receptor turnover for tissue repair. Nat Biotechnol 30, 835–836 (2012).

Download citation

Further reading


Quick links