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Channeling DNA for optical mapping

Nature Biotechnology volume 30, pages 762–763 (2012)Cite this article

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Stretching DNA molecules in nanochannels allows structural and copy-number variations to be visualized like beads on a string.

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Figure 1: Optical mapping with nanochannels.

References

  1. Treangen, T.J. & Salzberg, S.L. Nat. Rev. Genet. 13, 36–46 (2012).

    Article  CAS  Google Scholar 

  2. 1000 Genomes Project Consortium. Nature 467, 1061–1073 (2010).

  3. Lam, E.T. et al. Nat. Biotechnol. 30, 771–776 (2012).

    Article  CAS  Google Scholar 

  4. Zohar, H. & Muller, S.J. Nanoscale 3, 3027–3039 (2011).

    Article  CAS  Google Scholar 

  5. Samad, A., Huff, E.F., Cai, W. & Schwartz, D.C. Genome Res. 5, 1–4 (1995).

    Article  CAS  Google Scholar 

  6. Michalet, X. Science 277, 1518–1523 (1997).

    Article  CAS  Google Scholar 

  7. Baday, M. et al. Nano Lett. doi:10.1021/nl302069q (2012).

  8. Neely, R.K. et al. Chem. Sci. 1, 453–460 (2010).

    Article  CAS  Google Scholar 

  9. Kim, S. et al. Angew. Chem. Int. Ed. 51, 3578–3581 (2012).

    Article  CAS  Google Scholar 

  10. Fan, H.C., Wang, J., Potanina, A. & Quake, S.R. Nat. Biotechnol. 29, 51–57 (2011).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Yael Michaeli & Yuval Ebenstein are in the School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel.,

    Yael Michaeli & Yuval Ebenstein

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  1. Yael Michaeli
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  2. Yuval Ebenstein
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Correspondence to Yael Michaeli.

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The authors declare no competing financial interests.

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Michaeli, Y., Ebenstein, Y. Channeling DNA for optical mapping. Nat Biotechnol 30, 762–763 (2012). https://doi.org/10.1038/nbt.2324

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