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TAL effector RVD specificities and efficiencies

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Figure 1: TALE RVD specificities and efficiencies.


  1. Baker, M. Nat. Methods 9, 23–26 (2012).

    Article  CAS  Google Scholar 

  2. Bogdanove, A.J. & Voytas, D.F. Science 333, 1843–1846 (2011).

    Article  CAS  Google Scholar 

  3. DeFrancesco, L. Nat. Biotechnol. 29, 681–684 (2011).

    Article  Google Scholar 

  4. Miller, J.C. et al. Nat. Biotechnol. 29, 143–148 (2011).

    Article  CAS  Google Scholar 

  5. Boch, J. et al. Science 326, 1509–1512 (2009).

    Article  CAS  Google Scholar 

  6. Moscou, M.J. & Bogdanove, A.J. Science 326, 1501 (2009).

    Article  CAS  Google Scholar 

  7. Deng, D. et al. Science 335, 720–723 (2012).

    Article  CAS  Google Scholar 

  8. Mak, A.N., Bradley, P., Cernadas, R.A., Bogdanove, A.J. & Stoddard, B.L. Science 335, 716–719 (2012).

    Article  CAS  Google Scholar 

  9. Zhang, F. et al. Nat. Biotechnol. 29, 149–153 (2011).

    Article  Google Scholar 

  10. Morbitzer, R., Römer, P., Boch, J. & Lahaye, T. Proc. Natl. Acad. Sci. USA 107, 21617–21622 (2010).

    Article  CAS  Google Scholar 

  11. Huang, P. et al. Nat. Biotechnol. 29, 699–700 (2011).

    Article  Google Scholar 

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We thank R. Szczesny and T. Schreiber for helpful discussions on the manuscript, S. Thieme (Department of Genetics, Martin Luther University Halle-Wittenberg) for providing the binary vector, C. Kretschmer for expert technical assistance and U. Bonas for continued support. J.B. was supported by a grant from the Deutsche Forschungsgemeinschaft (SPP 1212).

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Correspondence to Jens Boch.

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J.B. is a part owner of a patent application regarding the use of TALs.

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Supplementary Figs. 1–7, Supplementary Tables 1,2 and Supplementary Methods (PDF 2498 kb)

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Streubel, J., Blücher, C., Landgraf, A. et al. TAL effector RVD specificities and efficiencies. Nat Biotechnol 30, 593–595 (2012).

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