Oligonucleotides with unnatural sugar backbones that can be replicated in vitro may open up new avenues for synthetic biology and beyond.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pinheiro, V.B. et al. Science 336, 341–344 (2012).
White, H.B. III. J. Mol. Evol. 7, 101–104 (1976).
Grosjean, H. Nucleic acids are not boring long polymers of only four types of nucleotides: a guided tour. in DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution (ed. Grosjean, H.) 1–18 (Landes Bioscience, Austin, Texas, 2009).
Tuerk, C. & Gold, L. Science 249, 505–510 (1990).
Ellington, A.D. & Szostak, J.W. Nature 346, 818–822 (1990).
Gold, L. et al. PLoS ONE 5, e15004 (2010).
Lanford, R.E. et al. Science 327, 198–201 (2010).
Joyce, G.F. Science 336, 307–308 (2012).
Gould, S.J. Wonderful Life: the Burgess Shale and the Nature of History (W.W. Norton & Company, New York; 1989).
Levene, P. J. Biol. Chem. 40, 415–424 (1919).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
F.S. and L.G. are employees and shareholders of SomaLogic.
Rights and permissions
About this article
Cite this article
Steele, F., Gold, L. The sweet allure of XNA. Nat Biotechnol 30, 624–625 (2012). https://doi.org/10.1038/nbt.2298
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt.2298