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Next-generation protein engineering targets influenza

Computational design and high-throughput mutational scanning yield proteins with subnanomolar affinities for influenza hemagglutinin.

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Figure 1: Use of next-generation sequencing to identify variants of designed proteins HB80.3 and HB36.4 that bind H1N1 influenza hemagglutinin with high affinity.


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Correspondence to Shoshana J Wodak.

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The author declares no competing financial interests.

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Wodak, S. Next-generation protein engineering targets influenza. Nat Biotechnol 30, 502–504 (2012).

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