Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

High-efficiency TALEN-based gene editing produces disease-resistant rice

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: High-efficiency targeted gene editing using TALENs.


  1. 1

    Yang, B., Sugio, A. & White, F.F. Proc. Natl. Acad. Sci. USA 103, 10503–10508 (2006).

    CAS  Article  Google Scholar 

  2. 2

    Antony, G. et al. Plant Cell 22, 3864–3876 (2010).

    CAS  Article  Google Scholar 

  3. 3

    Li, T. et al. Nucleic Acids Res. 39, 359–372 (2011).

    Article  Google Scholar 

  4. 4

    Christian, M. et al. Genetics 186, 757–761 (2010).

    CAS  Article  Google Scholar 

  5. 5

    Miller, J.C. et al. Nat. Biotechnol. 29, 143–148 (2011).

    CAS  Article  Google Scholar 

  6. 6

    Mahfouz, M.M. et al. Proc. Natl. Acad. Sci. USA 108, 2623–2628 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Cermak, T. et al. Nucleic Acids Res. 39, e82 (2011).

    CAS  Article  Google Scholar 

  8. 8

    Li, T. et al. Nucleic Acids Res. 39, 6315–6325 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Sander, J.D. et al. Nat. Biotechnol. 29, 697–698 (2011).

    CAS  Article  Google Scholar 

  10. 10

    Huang, P. et al. Nat. Biotechnol. 29, 699–700 (2011).

    Article  Google Scholar 

  11. 11

    Tesson, L. et al. Nat. Biotechnol. 29, 695–696 (2011).

    CAS  Article  Google Scholar 

  12. 12

    Wood, A.J. et al. Science 333, 307 (2011).

    CAS  Article  Google Scholar 

  13. 13

    Hockemeyer, D. et al. Nat. Biotechnol. 29, 731–734 (2011).

    CAS  Article  Google Scholar 

  14. 14

    Chen, L.Q. et al. Science 335, 207–211 (2012).

    CAS  Article  Google Scholar 

Download references


We thank D. Wright and C. Yao for helpful suggestions, L. Xue and J. Luo for technical assistance, and F.F. White and S. Howell for critical reading of the manuscript. This work was supported by grants from the US National Science Foundation (0820831 to B.Y., MCB-0952323 to M.H.S., and MCB-0952533 and EPSCoR grant 1004094 to D.P.W.).

Author information



Corresponding author

Correspondence to Bing Yang.

Ethics declarations

Competing interests

T.L., B.L. and B.Y. are inventors on a patent application covering TALEN-mediated rice engineering for disease resistance.

Supplementary information

Supplementary Text and Figures

Supplementary Methods, Supplementary Note and Supplementary Figures 1-11 (PDF 580 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Li, T., Liu, B., Spalding, M. et al. High-efficiency TALEN-based gene editing produces disease-resistant rice. Nat Biotechnol 30, 390–392 (2012).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing