Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

High-efficiency TALEN-based gene editing produces disease-resistant rice

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: High-efficiency targeted gene editing using TALENs.

References

  1. Yang, B., Sugio, A. & White, F.F. Proc. Natl. Acad. Sci. USA 103, 10503–10508 (2006).

    Article  CAS  Google Scholar 

  2. Antony, G. et al. Plant Cell 22, 3864–3876 (2010).

    Article  CAS  Google Scholar 

  3. Li, T. et al. Nucleic Acids Res. 39, 359–372 (2011).

    Article  Google Scholar 

  4. Christian, M. et al. Genetics 186, 757–761 (2010).

    Article  CAS  Google Scholar 

  5. Miller, J.C. et al. Nat. Biotechnol. 29, 143–148 (2011).

    Article  CAS  Google Scholar 

  6. Mahfouz, M.M. et al. Proc. Natl. Acad. Sci. USA 108, 2623–2628 (2011).

    Article  CAS  Google Scholar 

  7. Cermak, T. et al. Nucleic Acids Res. 39, e82 (2011).

    Article  CAS  Google Scholar 

  8. Li, T. et al. Nucleic Acids Res. 39, 6315–6325 (2011).

    Article  CAS  Google Scholar 

  9. Sander, J.D. et al. Nat. Biotechnol. 29, 697–698 (2011).

    Article  CAS  Google Scholar 

  10. Huang, P. et al. Nat. Biotechnol. 29, 699–700 (2011).

    Article  Google Scholar 

  11. Tesson, L. et al. Nat. Biotechnol. 29, 695–696 (2011).

    Article  CAS  Google Scholar 

  12. Wood, A.J. et al. Science 333, 307 (2011).

    Article  CAS  Google Scholar 

  13. Hockemeyer, D. et al. Nat. Biotechnol. 29, 731–734 (2011).

    Article  CAS  Google Scholar 

  14. Chen, L.Q. et al. Science 335, 207–211 (2012).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank D. Wright and C. Yao for helpful suggestions, L. Xue and J. Luo for technical assistance, and F.F. White and S. Howell for critical reading of the manuscript. This work was supported by grants from the US National Science Foundation (0820831 to B.Y., MCB-0952323 to M.H.S., and MCB-0952533 and EPSCoR grant 1004094 to D.P.W.).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bing Yang.

Ethics declarations

Competing interests

T.L., B.L. and B.Y. are inventors on a patent application covering TALEN-mediated rice engineering for disease resistance.

Supplementary information

Supplementary Text and Figures

Supplementary Methods, Supplementary Note and Supplementary Figures 1-11 (PDF 580 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, T., Liu, B., Spalding, M. et al. High-efficiency TALEN-based gene editing produces disease-resistant rice. Nat Biotechnol 30, 390–392 (2012). https://doi.org/10.1038/nbt.2199

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2199

This article is cited by

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research