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Selecting antigens for cancer vaccines

A cancer vaccine is streamlined by identifying a small set of potent immunogens in a tumor cDNA library.

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Figure 1: Screening to identify melanoma antigens in immune mice.

Katie Vicari

References

  1. Le, D.T., Pardoll, D.M. & Jaffee, E.M. Cancer J. 16, 304–310 (2010).

    Article  CAS  Google Scholar 

  2. Kottke, T. et al. Nat. Med. 17, 854–859 (2011).

    Article  CAS  Google Scholar 

  3. Vile, R. et al. Nat. Biotechnol. 30, 337–343 (2012).

    Article  Google Scholar 

  4. Naftzger, C. et al. Proc. Natl. Acad. Sci. USA 93, 14809–14814 (1996).

    Article  CAS  Google Scholar 

  5. Muranski, P. et al. Blood 112, 362–373 (2008).

    Article  CAS  Google Scholar 

  6. Avogadri, F. et al. PLoS One 5, e12670 (2010).

    Article  Google Scholar 

  7. Sharma, P., Wagner, K., Wolchok, J.D. & Allison, J.P. Nat. Rev. Cancer 11, 805–812 (2011).

    Article  CAS  Google Scholar 

  8. Quezada, S.A., Peggs, K.S., Curran, M.A. & Allison, J.P. J. Clin. Invest. 116, 1935–1945 (2006).

    Article  CAS  Google Scholar 

  9. van den Eertwegh, A.J.M. et al. Lancet Oncol., published online, doi:10.1016/S1470–2045 (10 February 2012).

  10. Schwartzentruber, D.J. et al. N. Engl. J. Med. 364, 2119–2127 (2011).

    Article  CAS  Google Scholar 

  11. Hodi, F.S. et al. N. Engl. J. Med. 363, 711–723 (2010).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Jedd D Wolchok.

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Competing interests

J.D.W. is a co-inventor on patents for xenogeneic DNA immunization and an alphavirus replicon particle vaccine for TRP2.

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Avogadri, F., Wolchok, J. Selecting antigens for cancer vaccines. Nat Biotechnol 30, 328–329 (2012). https://doi.org/10.1038/nbt.2174

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