Use of genome-wide association studies for drug repositioning

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Figure 1: Analysis pipeline.

References

  1. 1

    Kathiresan, S. et al. Nat. Genet. 40, 189–197 (2008).

  2. 2

    Franke, A. et al. Nat. Genet. 42, 1118–1125 (2010).

  3. 3

    Moschen, A.R. et al. Gut 54, 479–487 (2005).

  4. 4

    Stefansson, H. et al. Nat. Genet. 41, 277–279 (2009).

  5. 5

    Clark, L.N. et al. Eur. J. Hum. Genet. 18, 838–843 (2010).

  6. 6

    Louis, E.D. Lancet Neurol. 4, 100–110 (2005).

  7. 7

    Tobacco and Genetics Consortium. Nat. Genet. 42, 441–447 (2010).

  8. 8

    Stuart, P.E. et al. Nat. Genet. 42, 1000–1004 (2010).

  9. 9

    Ormerod, A.D. et al. Arch. Dermatol. Res. 290, 3–8 (1998).

  10. 10

    Ormerod, A.D. et al. Br. J. Dermatol. 142, 985–990 (2000).

  11. 11

    Welsh, P. et al. J. Clin. Endocrinol. Metab. 95, 93–99 (2010).

  12. 12

    Xu, K. & Coté, T.R. Brief. Bioinform. 12, 341–345 (2011).

  13. 13

    Nair, R.P. et al. Nat. Genet. 41, 199–204 (2009).

  14. 14

    Styrkarsdottir, U. et al. Nat. Genet. 41, 15–17 (2009).

  15. 15

    Zeggini, E. et al. Science 316, 1336–1341 (2007).

  16. 16

    Imielinski, M. et al. Nat. Genet. 41, 1335–1340 (2009).

  17. 17

    Barrett, J.C. et al. Nat. Genet. 40, 955–962 (2008).

  18. 18

    Anderson, C.A. et al. Nat. Genet. 43, 246–252 (2011).

  19. 19

    Dubois, P.C. et al. Nat. Genet. 42, 295–302 (2010).

  20. 20

    Baratz, K.H. et al. N. Engl. J. Med. 363, 1016–1024 (2010).

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Acknowledgements

The authors thank K. Peters for helpful comments on this manuscript. T.P. holds a Canada Research Chair and is supported by the Canadian Institutes of Health Research (CIHR). J.B.R. is supported by the CIHR, Ministere Développement Economique, Innovation et Exportation du Québec, Fonds de la Recherche en Santé du Québec, Lady Davis Institute of Medical Research.

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Correspondence to Philippe Sanseau.

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Competing interests

P.X.S. is a full-time employee of GlaxoSmithKline, a pharmaceutical company.

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