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Tracing the genesis of human embryonic stem cells

When human blastocysts are cultured in vitro to derive embryonic stem cells, they undergo profound molecular changes that alter their identity.

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Figure 1: Adaptation of human pluripotent cells during ESC derivation.


  1. O'Leary, B. Nat. Biotechnol. 30, 278–282 (2012).

    Article  CAS  Google Scholar 

  2. Nichols, J. & Smith, A. Cell Stem Cell 4, 487–492 (2009).

    Article  CAS  Google Scholar 

  3. Hanna, J. et al. Cell Stem Cell 4, 513–524 (2009).

    Article  CAS  Google Scholar 

  4. Guo, G. et al. Development 136, 1063–1069 (2009).

    Article  CAS  Google Scholar 

  5. Chu, L.F., Surani, M.A., Jaenisch, R. & Zwaka, T.P. Curr. Biol. 21, 1759–1765 (2011).

    Article  CAS  Google Scholar 

  6. Thomson, J.A. et al. Science 282, 1145–1147 (1998).

    Article  CAS  Google Scholar 

  7. Hanna, J. et al. Proc. Natl. Acad. Sci. USA 107, 9222–9227 (2010).

    Article  CAS  Google Scholar 

  8. Lengner, C.J. et al. Cell 141, 872–883 (2010).

    Article  CAS  Google Scholar 

  9. Okamoto, I. et al. Nature 472, 370–374 (2011).

    Article  CAS  Google Scholar 

  10. Tachibana, M. et al. Cell 148, 285–295 (2012).

    Article  CAS  Google Scholar 

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Correspondence to Jacob H Hanna.

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Pribluda, A., Hanna, J. Tracing the genesis of human embryonic stem cells. Nat Biotechnol 30, 247–249 (2012).

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