Antibiotic-resistant bacterial pathogens could be treated with combinations of drugs—if only we knew which combinations would work. Two studies from the same group have identified promising compounds that warrant further exploration. In a recent study, Shakya et al. focused on kinase inhibitors as bacterial kinases confer resistance to two important classes of antibiotics, aminoglycosides and macrolides. The researchers screened 80 kinase inhibitors against 14 bacterial kinases in vitro, identifying several active compounds including quercetin, a flavonoid found in many fruits and vegetables. Quercetin and the other top hits increased antibiotic efficacy in vivo. In an earlier paper (Ejim et al.), the authors screened a library of previously approved drugs for the ability to increase the potency of a known antibiotic, minocycline. They found that loperamide (Imodium), an over-the-counter treatment for diarrhea, increases bacterial uptake of minocycline and other antibiotics, thereby increasing efficacy. The authors note the compounds they identified can serve as starting points for further optimization. (Chem. Biol. 18, 1591–1601 (2011); Nat. Chem. Biol. 7, 348–350 (2011))