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Parallel genome universes

Nature Biotechnology volume 30, pages 55–56 (2012)Cite this article

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An Erratum to this article was published on 07 June 2012

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A new computational approach gives us the best chance at understanding how genomes are arranged in three-dimensional space and what that may mean for their function.

It is remarkable to realize that despite all the talk—and work—on genomes and their sequences, nobody knows how they are actually organized inside the cell1. The recent development of biochemical methods to probe global genome organization has given a glimmer of hope that systematic mapping of genomes in space will soon be possible. In this issue, Kalhor et al.2 report an improved experimental protocol and a breakthrough in how to analyze data from these approaches. The computational strategy provides a more realistic picture of the genome landscape and will help elucidate the links between genome organization and function.

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Figure 1: Population-based modeling of genome organization.

Change history

  • 07 June 2012

    In the version of this article initially published, the volume number and year of reference 2 should have been 30 and 2012, and not 29 and 2011, respectively. The errors have been corrected in the HTML and PDF versions of the article.

References

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  1. Tom Misteli is at the National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.

    Tom Misteli

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  1. Tom Misteli
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Correspondence to Tom Misteli.

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The author declares no competing financial interests.

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Misteli, T. Parallel genome universes. Nat Biotechnol 30, 55–56 (2012). https://doi.org/10.1038/nbt.2085

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