Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Patents
  • Published:

Pharmaceutical patent evaluation and licensing using a stochastic model and Monte Carlo simulations

The long-neglected patent value pattern must be considered when evaluating patents.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The S-shape curve life cycle of patent value.
Figure 2: The patent value obtained by 2,000 Monte Carlo simulations represents the life cycle as well as value uncertainty over a 20-year period.
Figure 3: Life cycle uncertainty, market sales uncertainty and upper/lower bounds of possible patent value.

References

  1. Anonymous. Pharmaceutical Licensing Overview (Datamonitor, 2010).

  2. Anonymous. Pharmaceutical Licensing Strategies. (Business-Insights, 2006).

  3. David, E., Tramontin, T. & Zemmel, R. Nat. Rev. Drug Discov. 8, 609–610 (2009).

    Article  CAS  Google Scholar 

  4. Villiger, R. & Bogdan, B. Nat. Biotechnol. 23, 423–428 (2005).

    Article  CAS  Google Scholar 

  5. Stewart, J.J., Allison, P.N. & Johnson, R.S. Nat. Biotechnol. 19, 813–817 (2001).

    Article  CAS  Google Scholar 

  6. Dixit, A. & Pindyck, R.S. Investment under Uncertainty (Princeton University Press, 1994).

    Google Scholar 

  7. Pindyck, R.S. Am. Econ. Rev. 78, 969–985 (1988).

    Google Scholar 

  8. Myers, S.C. J. Finance 29, 1–25 (1974).

    Article  Google Scholar 

  9. Kulatilaka, N. & Perotti, E.C. Manage. Sci. 44, 1021–1031 (1998).

    Article  Google Scholar 

  10. Kellogg, D. & Charnes, J.M. Financ. Anal. J. 56, 76–84 (2000).

    Article  Google Scholar 

  11. Schwartz, E.S. Econ. Notes 33, 23–54 (2004).

    Article  Google Scholar 

  12. Baudry, M. & Dumont, B. Rev. Ind. Organ. 28, 41–62 (2006).

    Google Scholar 

  13. Wu, M.C. & Tseng, C.Y. Appl. Econ. Lett. 13, 313–318 (2006).

    Article  Google Scholar 

  14. Myers, S.C. & Howe, C.D. A Life-Cycle Financial Model of Pharmaceutical R&D. Program on the Pharmaceutical Industry (Massachusetts Institute of Technology, 1997).

    Google Scholar 

  15. Burgess, P. et al. Nat. Biotechnol. 28, 1267–1270 (2010).

    Article  CAS  Google Scholar 

  16. Anonymous. The Biotechnology and Pharmaceutical Industries Program Office, Ministry of Economic Affairs (MOEA), Taiwan (2008). <http://www.biopharm.org.tw/en/>

Download references

Acknowledgements

L.C.W. contributed ideas, designed and performed experiments and data analysis and wrote the manuscript. L.H.W. contributed ideas, designed and performed experiments and wrote the manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lianghong Wu.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Methods and Supplementary Table 1 (PDF 262 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wu, L., Wu, L. Pharmaceutical patent evaluation and licensing using a stochastic model and Monte Carlo simulations. Nat Biotechnol 29, 798–801 (2011). https://doi.org/10.1038/nbt.1963

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.1963

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research