Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

First CHO genome

An ancestor of the Chinese hamster ovary cell lines used for production of recombinant therapeutics has been sequenced.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Genetic heterogeneity of CHO cell lines.


  1. Xu, X. et al. Nat. Biotechnol. 29, 735–741 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Puck, T.T., Cieciura, S.J. & Robinson, A. J. Exp. Med. 108, 945–956 (1958).

    Article  CAS  Google Scholar 

  3. Urlaub, G. & Chasin, L. Proc. Natl. Acad. Sci. USA 77, 4216–4220 (1980).

    Article  CAS  PubMed  Google Scholar 

  4. Urlaub, G., Käs, E., Carothers, A.M. & Chasin, L.A. Cell 33, 405–412 (1983).

    Article  CAS  PubMed  Google Scholar 

  5. Wurm, F.M. et al. Methotrexate and CHO cells: productivity and genetics of amplified expression vector sequences. in Production of Biologicals from Animal Cells in Culture (eds. Spier, R.E., Griffiths, J.B. & Meignier, B.) 316–326 (Butterworths, Oxford, 1990).

    Google Scholar 

  6. Deaven, L.L. & Petersen, D.F. Chromosoma 41, 129–144 (1973).

    Article  CAS  PubMed  Google Scholar 

  7. Kao, F.-T. & Puck, T.T. Nature 228, 329–332 (1970).

    Article  CAS  PubMed  Google Scholar 

  8. Derouazi, M. et al. Biochem. Biophys. Res. Commun. 340, 1069–1077 (2006).

    Article  CAS  PubMed  Google Scholar 

  9. Hsu, T.C. Int. Rev. Cytol. 12, 69–161 (1961).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Florian M Wurm.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wurm, F., Hacker, D. First CHO genome. Nat Biotechnol 29, 718–720 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing