Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Transgenic salmon: a final leap to the grocery shelf?

Despite being caught up in regulatory proceedings for 15 years or more, AquAdvantage salmon, the first animal genetically engineered (GE) for food purposes, continues to raise concerns. Are any of these concerns scientifically justified?

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    US Food and Drug Administration. FDA Final Guidance for Industry 187 Regulation of Genetically Engineered Animals Containing Heritable Recombinant DNA Constructs (FDA, Rockville, MD, January 2009). http://www.fda.gov/downloads/AnimalVeterinary/GuidanceComplinaceEnforcement/GuidanceforIndustry/UCM113903.pdf

  2. 2

    US Food and Drug Administration. FDA Veterinary Medicine Advisory Committee Briefing Packet AquAdvantage Salmon (FDA Center for Vete-rinary Medicine, Rockville, MD, September 2010). http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/VeterinaryMedicineAdvisoryCommittee/UCM.24762.pdf

  3. 3

    AquaBounty Technologies, Inc. Environmental Assessment for AquAdvantage® Salmon (ARCADISU.S., Inc., Highlands Ranch, CO, August 2010). http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/VeterinaryMedicineAdvisoryCommittee/UCM224760.pdf

  4. 4

    United Nations Food and Agriculture Organization and World Health Organization. Guideline for the Conduct of Food Safety Assessment of Foods Derived from Recombinant-DNA Animals (FAO/WHO, 2008) http://www.codexalimentarius.net/download/standards/11023/CXG_068e.pdf

  5. 5

    Nordlee, J.A., Taylor, S.L., Townsend, J.A., Thomas, L.A. & Bush, R.K. N. Engl. J. Med. 334, 688–692 (1996).

    Article  CAS  PubMed  Google Scholar 

  6. 6

    Goodman, R.E. et al. Nat. Biotechnol. 26, 73–81 (2008).

    Article  CAS  PubMed  Google Scholar 

  7. 7

    Sten, E. et al. APMIS 112, 21–28 (2004).

    Article  CAS  PubMed  Google Scholar 

  8. 8

    Sancho, A.I. et al. J. Agric. Food Chem. 54, 5917–5923 (2006).

    Article  CAS  PubMed  Google Scholar 

  9. 9

    Sancho, A.I. et al. J. Agric. Food Chem. 54, 5098–5104 (2006).

    Article  CAS  PubMed  Google Scholar 

  10. 10

    Marzban, G. et al. Plant Sci. 169, 387–394 (2005).

    Article  CAS  Google Scholar 

  11. 11

    Wild, L.G. & Lehrer, S.B. Curr. Allergy Asthma Rep. 5, 74–79 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. 12

    Lindstrom, C.D., van Do, T., Hordvik, I., Endresen, C. & Elsayed, S. Scand. J. Immunol. 44, 335–344 (1996).

    Article  CAS  PubMed  Google Scholar 

  13. 13

    Kuehn, A., Scheuermann, T., Hilger, C. & Hentges, F. Int. Arch. Allergy Immunol. 153, 359–366 (2010).

    Article  CAS  PubMed  Google Scholar 

  14. 14

    Pollack, A. Modified salmon is safe, F.D.A. says. New York Times (September 3, 2010)

  15. 15

    Hansen, M. Comments of Consumers Union on genetically engineered salmon, FDA docket no. FDA-201034-N-0001, VMAC Meeting, 16 September 2010 http://www.consumersunion.org/pdf/CU-comments-GE-salmon-0910.pdf

  16. 16

    National Research Council. Committee on Defining Science-Based Concerns Associated with Products of Animal Biotechnology. Animal Biotechnology: Science-Based Concerns. (The National Academies Press, Washington DC, 2002).

  17. 17

    Muir, W.M. EMBO Rep. 5, 654–659 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. 18

    Muir, W.M. & Howard, R.D. Transgenic Res. 11, 101–114 (2002).

    Article  CAS  PubMed  Google Scholar 

  19. 19

    Moreau, D.T.R. Conway, C., & Flemming, I.A. Evol. Appl., (July 2011) DOI:10.1111/j.1752-4571.2011.00196.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. 20

    Muir, W.M. & Howard, R.D. Am. Nat. 158, 1–16 (2001).

    Article  CAS  PubMed  Google Scholar 

  21. 21

    Muir, W.M. & Howard, R.D. Proc. Natl. Acad. Sci. USA 96, 13853–13856 (1999).

    Article  CAS  PubMed  Google Scholar 

  22. 22

    Conko, G. & Miller, H.I. Nat. Biotechnol. 28, 1256–1258 (2010).

    Article  CAS  PubMed  Google Scholar 

  23. 23

    Schiermeier, Q. Nature 425, 753 (2003).

    Article  CAS  PubMed  Google Scholar 

  24. 24

    Lynch, M. & O'Hely, M. Conserv. Genet. 2, 363–378 (2001).

    Article  Google Scholar 

  25. 25

    Young, D. Rep. Young's Frankenfish amendment passes. http://donyoung.house.gov/News/DocumentSingle.aspx?DocumentID=247046 (16 June 2011)

  26. 26

    Worm, B. et al. Science 314, 787–790 (2006).

    Article  CAS  PubMed  Google Scholar 

  27. 27

    Lyall, J. et al. Science 331, 223–226 (2011).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Alison L Van Eenennaam.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Van Eenennaam, A., Muir, W. Transgenic salmon: a final leap to the grocery shelf?. Nat Biotechnol 29, 706–710 (2011). https://doi.org/10.1038/nbt.1938

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing