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Finding the niche for human somatic cell nuclear transfer

Nature Biotechnology volume 29, pages 701–705 (2011)Cite this article

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Does human somatic cell nuclear transfer have a future after the discovery of induced pluripotent stem cells?

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Figure 1: Unique opportunities for human nuclear transfer technology.

References

  1. California Institute for Regenerative Medicine and the Medical Research Council of the United Kingdom. Human Somatic Cell Nuclear Transfer Workshop Report (CIRM, MRC; 13,14 June 2010) http://www.cirm.ca.gov/MeetingReports.

  2. Gurdon, J.B. Dev. Biol. 4, 256–273 (1962).

    Article  CAS  PubMed  Google Scholar 

  3. Wilmut, I., Schnieke, A.E., McWhir, J., Kind, A.J. & Campbell, K.H. Nature 385, 810–813 (1997).

    Article  CAS  PubMed  Google Scholar 

  4. Thomson, J.A. et al. Science 282, 1145–1147 (1998).

    Article  CAS  PubMed  Google Scholar 

  5. Munsie, M.J. et al. Curr. Biol. 10, 989–992 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Takahashi, K. et al. Cell 131, 861–872 (2007).

    Article  CAS  PubMed  Google Scholar 

  8. Yu, J. et al. Science 318, 1917–1920 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Byrne, J.A. et al. Nature 450, 497–502 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. French, A.J. et al. Stem Cells 26, 485–493 (2008).

    Article  CAS  PubMed  Google Scholar 

  11. Li, J. et al. Cloning Stem Cells 11, 39–50 (2009).

    Article  CAS  PubMed  Google Scholar 

  12. Fan, Y. et al. Stem Cells Dev. (in the press).

  13. Li, J. et al. Proc. Natl. Acad. Sci. USA 107, 10280–10284 (2010).

    Article  PubMed  Google Scholar 

  14. McElroy, S.L. et al. PLoS ONE 5, e10979 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Kee, K., Angeles, V.T., Flores, M., Nguyen, H.N. & Reijo Pera, R.A. Nature 462, 222–225 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Tecirlioglu, R.T., Guo, J. & Trounson, A.O. Stem Cell Rev. 2, 277–287 (2006).

    Article  CAS  PubMed  Google Scholar 

  17. Panarace, M. et al. Theriogenology 67, 142–151 (2007).

    Article  CAS  PubMed  Google Scholar 

  18. Brambrink, T., Hochedlinger, K., Bell, G. & Jaenisch, R. Proc. Natl. Acad. Sci. USA 103, 933–938 (2006).

    Article  CAS  PubMed  Google Scholar 

  19. Kim, K. et al. Nature 467, 285–290 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Polo, J.M. et al. Nat. Biotechnol. 28, 848–855 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Stadtfeld, M. et al. Nature 465, 175–181 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Boulting, G.L. et al. Nat. Biotechnol. 29, 279–286 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Ohtsuka, S. & Dalton, S. Gene Ther. 15, 74–81 (2008).

    Article  CAS  PubMed  Google Scholar 

  24. Maruotti, J. et al. Stem Cells 28, 743–752 (2010).

    Article  CAS  PubMed  Google Scholar 

  25. Urbach, A., Bar-Nur, O., Daley, G.Q. & Benvenisty, N. Cell Stem Cell 6, 407–411 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Warren, L. et al. Cell Stem Cell 7, 618–630 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Halley-Stott, R.P. et al. Methods 51, 56–65 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Pera, M.F. Nature 471, 46–47 (2011).

    Article  CAS  PubMed  Google Scholar 

  29. Zhao, T., Zhang, Z.N., Rong, Z. & Xu, Y. Nature 474, 212–215 (2011).

    Article  CAS  PubMed  Google Scholar 

  30. Poulton, J. et al. PLoS Genet. 6, e1001066 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Tachibana, M. et al. Nature 461, 367–372 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Craven, L. et al. Nature 465, 82–85 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We thank all participants in the CIRM-MRC hSCNT workshop for their valuable contributions to the discussions that took place, which formed the basis for this commentary. We also thank G. Lomax for contributions and Z. Scheiner for critical reading of this commentary, and A. Kutach for help with creating the figure. As we were unable to cite all relevant articles in this brief commentary, we apologize to those who were affected.

Author information

Authors and Affiliations

  1. Alan Trounson, Uta Grieshammer and Kelly A. Shepard are at the California Institute for Regenerative Medicine, San Francisco, California, USA.,

    Uta Grieshammer, Kelly A Shepard & Alan Trounson

  2. Elizabeth A. Nigh is with Science Editors in Palo Alto, California, USA.,

    Elizabeth A Nigh

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  1. Uta Grieshammer
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  2. Kelly A Shepard
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Correspondence to Uta Grieshammer.

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Grieshammer, U., Shepard, K., Nigh, E. et al. Finding the niche for human somatic cell nuclear transfer. Nat Biotechnol 29, 701–705 (2011). https://doi.org/10.1038/nbt.1933

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