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Streamlining biomarker discovery

Nature Biotechnology volume 29, pages 600–602 (2011)Cite this article

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Integrating targeted mass spectrometry into proteomic pipelines speeds the validation of disease biomarkers.

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Figure 1: A generic workflow for comprehensive biomarker discovery.

References

  1. Weston, A.D. & Hood, L. J. Proteome Res. 3, 179–196 (2004).

    Article  CAS  Google Scholar 

  2. Whiteaker, J.R. et al. Nat. Biotechnol. 29, 625–634 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Addona, T.A. et al. Nat. Biotechnol. 29, 635–643 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Jaffe, J.D. et al. Mol. Cell. Proteomics 7, 1952–1962 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ong, S.E. et al. Mol. Cell. Proteomics 1, 376–386 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Wu, W.W. et al. J. Proteome Res. 5, 651–658 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Blonder, J., Issaq, H.J. & Veenstra, T.D. Electrophoresis published online, doi:10.1002/elps.201000585 (9 May 2011).

  8. Ray, S. et al. Proteomics 11, 2139–2161 (2011).

    Article  CAS  PubMed  Google Scholar 

  9. Lu, B., Xu, T., Park, S.K. & Yates, J.R. Methods Mol. Biol. 564, 261–288 (2009).

    Article  CAS  PubMed  Google Scholar 

  10. Griffin, N.M. et al. Nat. Biotechnol. 28, 83–89 (2010).

    Article  CAS  PubMed  Google Scholar 

  11. Paweletz, C.P. et al. J. Proteome Res. 9, 1392–1401 (2010).

    Article  CAS  PubMed  Google Scholar 

  12. Latterich, M., Abramovitz, M. & Leyland-Jones, B. Eur. J. Cancer 44, 2737–2741 (2008).

    Article  CAS  PubMed  Google Scholar 

  13. Denham, J.W. et al. Cancer 115, 4477–4487 (2009) (2009).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Martin Latterich and Jan E. Schnitzer are at the Proteogenomics Research Institute for Systems Medicine, San Diego, California, USA.,

    Martin Latterich & Jan E Schnitzer

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  1. Martin Latterich
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  2. Jan E Schnitzer
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Correspondence to Martin Latterich or Jan E Schnitzer.

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The authors declare no competing financial interests.

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Latterich, M., Schnitzer, J. Streamlining biomarker discovery. Nat Biotechnol 29, 600–602 (2011). https://doi.org/10.1038/nbt.1917

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