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Sialidase inhibitors DAMPen sepsis

Nature Biotechnology volume 29, pages 406–407 (2011)Cite this article

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Sepsis can be ameliorated by small-molecule inhibitors of bacterial sialidases.

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Figure 1: Sialidase (neuraminidase) from bacterial pathogens disrupts the Siglec circuit that suppresses TLR signaling by DAMPs.

Katie Vicari

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Authors and Affiliations

  1. James C. Paulson and Norihito Kawasaki are in the Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, USA.,

    James C Paulson & Norihito Kawasaki

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  1. James C Paulson
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  2. Norihito Kawasaki
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Correspondence to James C Paulson.

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Paulson, J., Kawasaki, N. Sialidase inhibitors DAMPen sepsis. Nat Biotechnol 29, 406–407 (2011). https://doi.org/10.1038/nbt.1859

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