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Chemoproteomics quantifies complexity

Nature Biotechnology volume 29, pages 235–236 (2011)Cite this article

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The affinities of small molecules for proteins in megadalton complexes can be measured by mass spectrometry.

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Figure 1: The affinities of small molecules for HDAC1 and HDAC2 can be studied at multiple levels of complexity.

References

  1. Bantscheff, M. et al. Nat. Biotechnol. 29, 255–265 (2011).

    Article  CAS  Google Scholar 

  2. Zheng, X.-F. et al. Cell 82, 121–130 (1995).

    Article  CAS  Google Scholar 

  3. Sarbassov, D.D. Curr. Biol. 14, 1296–1302 (2004).

    Article  CAS  Google Scholar 

  4. Taunton, J., Hassig, C.A. & Schreiber, S.L. Science 272, 408–411 (1996).

    Article  CAS  Google Scholar 

  5. Dey, P. Curr. Med. Chem. 13, 2909–2919 (2006).

    Article  CAS  Google Scholar 

  6. Kazantsev, A.G. & Thompson, L.M. Nature Drug Dis. 7, 854–868 (2008).

    Article  CAS  Google Scholar 

  7. Brunmeir, R. et al. Int. J. Dev. Biol. 53, 275–289 (2009).

    Article  CAS  Google Scholar 

  8. Bantscheff, M. et al. Nat. Biotechnol. 25, 1035–1044 (2007).

    Article  CAS  Google Scholar 

  9. Hoshi, N. et al. Mol. Cell 37, 541–550 (2010).

    Article  CAS  Google Scholar 

Download references

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  1. Edward B. Holson and Stuart L. Schreiber are at the Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.,

    Edward B Holson & Stuart L Schreiber

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  1. Edward B Holson
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  2. Stuart L Schreiber
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Correspondence to Edward B Holson or Stuart L Schreiber.

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The authors declare no competing financial interests.

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Holson, E., Schreiber, S. Chemoproteomics quantifies complexity. Nat Biotechnol 29, 235–236 (2011). https://doi.org/10.1038/nbt.1804

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