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TALEs of genome targeting

Nature Biotechnology volume 29, pages 135–136 (2011)Cite this article

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New tools for site-specific genome targeting in human cells are generated from TALE proteins.

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Figure 1: Engineered TALEs function as programmable transcriptional activators and nucleases in human cells.

References

  1. Bonas, U., Stall, R.E. & Staskawicz, B.J. Mol. Gen. Genet. 218, 127–136 (1989).

    Article  CAS  Google Scholar 

  2. Boch, J. et al. Science 326, 1509–1512 (2009).

    Article  CAS  Google Scholar 

  3. Christian, M. et al. Genetics 186, 757–761 (2010).

    Article  CAS  Google Scholar 

  4. Morbitzer, R., Römer, P., Boch, J. & Lahaye, T. Proc. Natl. Acad. Sci. USA 107, 21617–21622 (2010).

    Article  CAS  Google Scholar 

  5. Miller, J.C. et al. Nat. Biotechnol. 29, 143–148 (2011).

    Article  CAS  Google Scholar 

  6. Zhang, F. et al. Nat. Biotechnol. 29, 149–153 (2011).

    Article  Google Scholar 

  7. Urnov, F.D., Rebar, E.J., Holmes, M.C., Zhang, H.S. & Gregory, P.D. Nat. Rev. Genet. 11, 636–646 (2010).

    Article  CAS  Google Scholar 

  8. Boch, J. & Bonas, U. Annu. Rev. Phytopathol. 48, 419–436 (2010).

    Article  CAS  Google Scholar 

  9. Moscou, M.J. & Bogdanove, A.J. Science 326, 1501 (2009).

    Article  CAS  Google Scholar 

  10. Li, T. et al. Nucleic Acids Res. 39, 359–372 (2011).

    Article  Google Scholar 

  11. Kay, S., Hahn, S., Marois, E., Hause, G. & Bonas, U. Science 318, 648–651 (2007).

    Article  CAS  Google Scholar 

  12. Engler, C., Kandzia, R. & Marillonnet, S. PLoS ONE 3, e3647 (2008).

    Article  Google Scholar 

Download references

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  1. Jens Boch is in the Department of Genetics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.,

    Jens Boch

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  1. Jens Boch
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Correspondence to Jens Boch.

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Boch, J. TALEs of genome targeting. Nat Biotechnol 29, 135–136 (2011). https://doi.org/10.1038/nbt.1767

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