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Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project

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Figure 1: The eighteen highest-ranked ad hoc concepts, according to Table 1.


  1. Quackenbush, J. Standardizing the standards. Mol. Syst. Biol. 2, 2006.0010 (2006).

  2. Anonymous. Under the MIAME sun. Nat. Methods 3, 415 (2006).

  3. Brazma, A. et al. Minimum information about a microarray experiment (MIAME)—toward standards for microarray data. Nat. Genet. 29, 365–371 (2001).

    Article  CAS  Google Scholar 

  4. Anonymous. Microarray standards at last. Nature 419, 323 (2002).

  5. Ball, C.A. et al. A guide to microarray experiments—an open letter to the scientific journals. Lancet 360, 1019 (2002).

    Article  Google Scholar 

  6. Ball, C.A. et al. Standards for microarray data. Science 298, 539 (2002).

    Article  CAS  Google Scholar 

  7. Ball, C.A. et al. The underlying principles of scientific publication. Bioinformatics 18, 1409 (2002).

    Article  CAS  Google Scholar 

  8. Taylor, C.F. et al. The minimum information about a proteomics experiment (MIAPE). Nat. Biotechnol. 25, 887–893 (2007).

    Article  CAS  Google Scholar 

  9. Le Novère, N. et al. Minimum information requested in the annotation of biochemical models (MIRIAM). Nat. Biotechnol. 23, 1509–1515 (2005).

    Article  Google Scholar 

  10. Altman, D.G., Simera, I., Hoey, J., Moher, D. & Schulz, K. EQUATOR: reporting guidelines for health research. Lancet 371, 1149–1150 (2008).

    Article  Google Scholar 

  11. Field, D. & Sansone, S.-A. A special issue on data standards. OMICS 10, 84–93 (2006).

    Article  CAS  Google Scholar 

  12. Morrison, N. et al. Concept of sample in OMICS technology. OMICS 10, 127–137 (2006).

    Article  CAS  Google Scholar 

  13. Morrison, N. et al. Standard annotation of environmental OMICS data: application to the transcriptomics domain. OMICS 10, 172–178 (2006).

    Article  CAS  Google Scholar 

  14. Jones, A.R. et al. The Functional Genomics Experiment model (FuGE): an extensible framework for standards in functional genomics. Nat. Biotechnol. 25, 1127–1133 (2007).

    Article  CAS  Google Scholar 

  15. Sansone, S.-A. et al. A strategy capitalizing on synergies: the Reporting Structure for Biological Investigation (RSBI) working group. OMICS 10, 164–171 (2006).

    Article  CAS  Google Scholar 

  16. Sansone, S.-A. et al. The first RSBI (ISA-TAB) workshop: “Can a simple format work for complex studies?” OMICS published online, doi:10.1089/omi.2008.0019 (2008).

  17. Smith, B. et al. The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration. Nat. Biotechnol. 25, 1251–1255 (2007).

    Article  CAS  Google Scholar 

  18. Taylor, C.F. et al. The work of the Human Proteome Organisation's Proteomics Standards Initiative (HUPO PSI). OMICS 10, 145–151 (2006).

    Article  CAS  Google Scholar 

  19. Fiehn, O. et al. Establishing reporting standards for metabolomic and metabonomic studies: a call for participation. OMICS 10, 158–163 (2006).

    Article  CAS  Google Scholar 

  20. Field, D. et al. The minimum information about a genome sequence (MIGS) specification. Nat. Biotechnol. 26, 541–547 (2008).

    Article  CAS  Google Scholar 

  21. Deutsch, E.W. et al. Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat. Biotechnol. 26, 305–312 (2008).

    Article  CAS  Google Scholar 

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We. acknowledge funding from the UK Natural Environmental Research Council's Environmental Bioinformatics Centre and the UK Biotechnology and Biological Sciences Research Council (BB/E025080/1) to D.F. and S.-A.S. to support C.F.T. and MIBBI. Work on MIFlowCyt is supported by the US National Institutes of Health's National Institute of Biomedical Imaging and Bioengineering (EB005034-01) and by Bioinformatics Integration Support Contract A140076 from the US National Institute of Allergy and Infectious Diseases. R.R.B. is supported by the Michael Smith Foundation for Health Research, by the International Society for the Advancement of Cytology and by grant funding from the US National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (R01EB005034). N.W.H. acknowledges the support of the European Union Framework VI project META-PHOR (Food-ST-2006-03622). F.G., P.L. and work on CARMEN are supported by the UK Engineering and Physical Sciences Research Council (EP/E002331/1). K.T. acknowledges support from Science Foundation Ireland. Work on MIAME/Tox and MIAME/Nutr by P.R-S. is supported by the NuGO (NoE 503630) and CarcinoGenomics (PL 037712) European Union projects. Work on MIARE is supported by the eDIKT project. Opinions, findings and conclusions or recommendations expressed in this paper are those of the authors and do not necessarily reflect the views of the US National Science Foundation or the US National Institutes of Health.

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Correspondence to Chris F Taylor, Dawn Field or Susanna-Assunta Sansone.

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Competing interests

D.F., S.-A.S. and C.F.T. conceived and designed the concept of MIBBI as synergistic project; D.F. and S.-A.S. raised the funds to support MIBBI activities, and C.F.T. performed the analysis presented in this paper; all authors discussed the results and implications and commented on the manuscript.

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Taylor, C., Field, D., Sansone, SA. et al. Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol 26, 889–896 (2008).

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