Behavioural studies indicate that a newly acquired motor skill is rapidly consolidated from an initially unstable state to a more stable state1, whereas neuroimaging studies demonstrate that the brain engages new regions for performance of the task as a result of this consolidation2. However, it is not known where a new skill is retained and processed before it is firmly consolidated. Some early aspects of motor skill acquisition involve the primary motor cortex (M1)3, but the nature of that involvement is unclear. We tested the possibility that the human M1 is essential to early motor consolidation. We monitored changes in elementary motor behaviour while subjects practised fast finger movements that rapidly improved in movement acceleration and muscle force generation. Here we show that low-frequency, repetitive transcranial magnetic stimulation of M1 but not other brain areas specifically disrupted the retention of the behavioural improvement, but did not affect basal motor behaviour, task performance, motor learning by subsequent practice, or recall of the newly acquired motor skill. These findings indicate that the human M1 is specifically engaged during the early stage of motor consolidation.
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Brashers-Krug, T., Shadmehr, R. & Bizzi, E. Consolidation in human motor memory. Nature 382, 252–255 (1996)
Shadmehr, R. & Holcomb, H. H. Neural correlates of motor memory consolidation. Science 277, 821–825 (1997)
Karni, A. et al. Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature 377, 155–158 (1995)
Honda, M. et al. Dynamic cortical involvement in implicit and explicit motor sequence learning. A PET study. Brain 121, 2159–2173 (1998)
Muellbacher, W., Ziemann, U., Boroojerdi, B., Cohen, L. & Hallett, M. Role of human primary motor cortex in rapid motor learning. Exp. Brain Res. 136, 431–438 (2001)
Jenkins, I. H., Brooks, D. J., Nixon, P. D., Frackowiak, R. S. & Passingham, R. E. Motor sequence learning: a study with positron emission tomography. J. Neurosci. 14, 3775–3790 (1994)
Nudo, R. J., Milliken, G. W., Jenkins, W. M. & Merzenich, M. M. Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. J. Neurosci. 16, 785–807 (1996)
Classen, J., Liepert, J., Wise, S. P., Hallett, M. & Cohen, L. G. Rapid plasticity of human cortical movement representation induced by practice. J. Neurophysiol. 79, 1117–1123 (1998)
Wassermann, E. M. et al. Use and safety of a new repetitive transcranial magnetic stimulator. Electroencephalogr. Clin. Neurophysiol. 101, 412–417 (1996)
Chen, R. et al. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology 48, 1398–1403 (1997)
Kosslyn, S. et al. The role of area 17 in visual imagery: convergent evidence from PET and rTMS. Science 284, 167–170 (1999)
Abbott, L. F., Varela, J. A., Sen, K. & Nelson, S. B. Synaptic depression and cortical gain control. Science 275, 220–224 (1997)
Hess, G. & Donoghue, J. P. Long-term potentiation and long-term depression of horizontal connections in rat motor cortex. Acta Neurobiol. Exp. (Warsz) 56, 397–405 (1996)
Gerloff, C., Corwell, B., Chen, R., Hallett, M. & Cohen, L. G. The role of the human motor cortex in the control of complex and simple finger movement sequences. Brain 121, 1695–1709 (1998)
Paus, T. et al. Transcranial magnetic stimulation during positron emission tomography: a new method for studying connectivity of the human cerebral cortex. J. Neurosci. 17, 3178–3184 (1997)
Hess, G., Aizenman, C. D. & Donoghue, J. P. Conditions for the induction of long-term potentiation in layer II/III horizontal connections of the rat motor cortex. J. Neurophysiol. 75, 1765–1778 (1996)
Hess, G. & Donoghue, J. P. Long-term depression of horizontal connections in rat motor cortex. Eur. J. Neurosci. 8, 658–665 (1996)
Rioult-Pedotti, M. S., Friedman, D., Hess, G. & Donoghue, J. P. Strengthening of horizontal cortical connections following skill learning. Nature Neurosci. 1, 230–234 (1998)
Rioult-Pedotti, M., Friedman, D. & Donoghue, J. Learning-induced LTP in neocortex. Science 290, 533–536 (2000)
Gandolfo, F., Li, C., Benda, B. J., Schioppa, C. P. & Bizzi, E. Cortical correlates of learning in monkeys adapting to a new dynamical environment. Proc. Natl Acad. Sci. USA 97, 2259–2263 (2000)
Li, C. S., Padoa-Schioppa, C. & Bizzi, E. Neuronal correlates of motor performance and motor learning in the primary motor cortex of monkeys adapting to an external force field. Neuron 30, 593–607 (2001)
Wassermann, E. M. Risk and safety of repetitive transcranial magnetic stimulation: Report and suggested guidelines from the international workshop on the safety of repetitive transcranial magnetic stimulation. June 5–7, 1996. Electroencephalogr. Clin. Neurophysiol. 108, 1–16 (1998)
Pascual-Leone, A., Wassermann, E. M., Grafman, J. & Hallett, M. The role of the dorsolateral prefrontal cortex in implicit procedural learning. Exp. Brain Res. 107, 479–485 (1996)
We thank our subjects for their cooperation, J.-P. Ndayisaba for technical assistance, and D. G. Schoenberg for editing. W.M. was supported by the Max Kade Foundation.
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Muellbacher, W., Ziemann, U., Wissel, J. et al. Early consolidation in human primary motor cortex. Nature 415, 640–644 (2002). https://doi.org/10.1038/nature712
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