13 Impact of evolutionary selection on functional regions

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    The imprint of evolutionary selection on ENCODE regulatory elements is manifested between species and within human populations.

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    Figure 1: Impact of selection on ENCODE functional elements in mammals and human populations.
    Figure 3: Motif mutational load of Drosophila and human TFBSs located within different genomic contexts
    Figure 5: Evidence for the 'buffering' of variation at conserved CTCF binding sites.
    Figure 7: SNP and indel DAF spectra are shown for transcribed and non-transcribed pseudogenes.
    Figure 7: Genetic variation in regulatory DNA linked to mutation rate.
    Figure 2: Characteristics of regulatory variation among individuals.
    Figure 4: Heterogeneity of polymorphism across cell types.

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    13 Impact of evolutionary selection on functional regions. Nature (2019) doi:10.1038/nature28182

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