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1 Transcription factor motifs

ENCODE discovers many new transcription-factor-binding-site motifs and explores their properties

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Figure 1: De novo discovery of sequence motifs.
Figure 2: Individual variation of the binding sites for 15 Drosophila and 36 human TFs selected for this study.
Figure 3: Motif mutational load of Drosophila and human TFBSs located within different genomic contexts.
Figure 2: Characterization of functional YY1 binding sites.
Figure 2: Interactions between TFs.
Figure 3: Binding sites of certain TFs or TF pairs are enriched in repeats.
Figure 4: Cell-type-specific binding of sequence-specific and non-sequence-specific TFs.
Figure 5: A genome-wide map of distal DHS-to-promoter connectivity.
Supplementary Figure 15: Statistical significance of co-occurences of motif families.
Figure 6: De novo motif discovery expands the human regulatory lexicon.
Figure 7: Multi-lineage DNase I footprinting reveals cell-selective gene regulators.
Figure 6: Cell-type-specific TF binding is associated with differential DNase accessibility, sequence signal, or both.
Figure 8: Cell-type-specific sequence models can predict cell-type-specific binding at loci that are DNase accessible in both cell lines.
Figure 2: Motif Analysis.

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1 Transcription factor motifs. Nature (2019). https://doi.org/10.1038/nature28170

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  • DOI: https://doi.org/10.1038/nature28170

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