1 Transcription factor motifs

    Article metrics

    • 35 Accesses

    ENCODE discovers many new transcription-factor-binding-site motifs and explores their properties

    Access options

    Rent or Buy article

    Get time limited or full article access on ReadCube.

    from$8.99

    All prices are NET prices.

    Figure 2: Individual variation of the binding sites for 15 Drosophila and 36 human TFs selected for this study.
    Figure 3: Motif mutational load of Drosophila and human TFBSs located within different genomic contexts.
    Figure 2: Characterization of functional YY1 binding sites.
    Figure 1: De novo discovery of sequence motifs.
    Figure 2: Interactions between TFs.
    Figure 3: Binding sites of certain TFs or TF pairs are enriched in repeats.
    Figure 4: Cell-type-specific binding of sequence-specific and non-sequence-specific TFs.
    Figure 5: A genome-wide map of distal DHS-to-promoter connectivity.
    Supplementary Figure 15: Statistical significance of co-occurences of motif families.
    Figure 6: De novo motif discovery expands the human regulatory lexicon.
    Figure 7: Multi-lineage DNase I footprinting reveals cell-selective gene regulators.
    Figure 6: Cell-type-specific TF binding is associated with differential DNase accessibility, sequence signal, or both.
    Figure 8: Cell-type-specific sequence models can predict cell-type-specific binding at loci that are DNase accessible in both cell lines.
    Figure 2: Motif Analysis.

    Rights and permissions

    Reprints and Permissions

    About this article

    Verify currency and authenticity via CrossMark

    Cite this article

    1 Transcription factor motifs. Nature (2019) doi:10.1038/nature28170

    Download citation

    Comments

    By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.