Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Thread
  • Published:

1 Transcription factor motifs

Nature (2019)Cite this article

ENCODE discovers many new transcription-factor-binding-site motifs and explores their properties

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: De novo discovery of sequence motifs.
Figure 2: Individual variation of the binding sites for 15 Drosophila and 36 human TFs selected for this study.
Figure 3: Motif mutational load of Drosophila and human TFBSs located within different genomic contexts.
Figure 2: Characterization of functional YY1 binding sites.
Figure 2: Interactions between TFs.
Figure 3: Binding sites of certain TFs or TF pairs are enriched in repeats.
Figure 4: Cell-type-specific binding of sequence-specific and non-sequence-specific TFs.
Figure 5: A genome-wide map of distal DHS-to-promoter connectivity.
Supplementary Figure 15: Statistical significance of co-occurences of motif families.
Figure 6: De novo motif discovery expands the human regulatory lexicon.
Figure 7: Multi-lineage DNase I footprinting reveals cell-selective gene regulators.
Figure 6: Cell-type-specific TF binding is associated with differential DNase accessibility, sequence signal, or both.
Figure 8: Cell-type-specific sequence models can predict cell-type-specific binding at loci that are DNase accessible in both cell lines.
Figure 2: Motif Analysis.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

1 Transcription factor motifs. Nature (2019). https://doi.org/10.1038/nature28170

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/nature28170

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing