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Lens regeneration in children

Nature volume 556, pages E2–E3 (2018)Cite this article

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ARISING FROM H. Lin et al. Nature 531, 323–328 (2016); doi:https://doi.org/10.1038/nature17181

Congenital cataracts are the primary cause of treatable childhood blindness worldwide, affecting about four infants per 10,000 live births1. Current surgical techniques have helped thousands of patients, but the limitations of these techniques2,3,4 led Lin et al.5 to report an alternative approach that they claim leads to a regenerated lens with refractive capacity. We have concerns regarding features of the presented data and the conclusions reached in the Article. This has implications for our patients who ask for such surgical intervention. There is a Reply to this Comment by Liu, Y. et al. Nature 556, https://doi.org/10.1038/nature26150 (2018).

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA

    Demetrios G. Vavvas, Ankoor Shah, Ula Jurkunas, Roberto Pineda, Vasiliki Poulaki, David G. Hunter, Louis R. Pasquale, Joan W. Miller & Deborah VanderVeen

  2. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Demetrios G. Vavvas, Ula Jurkunas, Roberto Pineda, Louis R. Pasquale & Joan W. Miller

  3. Department of Ophthalmology, Ocular Pathology Service, Massachusetts Eye and Ear Infirmary ,Harvard Medical School, Boston, Massachusetts, USA

    Thaddeus P. Dryja

  4. Albert Florens Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA

    M. Edward Wilson

  5. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA

    Timothy W. Olsen

  6. Department of Ophthalmology, Boston Children’s Hospital, Boston, Massachusetts, USA

    Ankoor Shah, David G. Hunter & Deborah VanderVeen

  7. Department of Ophthalmology, Veterans Affairs Hospital, Boston University, Boston, Massachusetts, USA

    Vasiliki Poulaki

  8. Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA

    Sotiria Palioura

  9. Department of Ophthalmology, University of Chicago, Chicago, Illinois, USA

    Peter Veldman & Kathryn Colby

  10. Department of Ophthalmology, University of Navarra, Pamplona, Spain

    Javier Moreno-Montañés

  11. Ophthalmic Research Unit “Santiago Grisolía” and Cellular and Molecular Ophthalmobiology Group at the Department of Ophthalmology, University of Valencia, Valencia, Spain

    Maria D. Pinazo-Duran

  12. Department of Ophthalmology, Hospital Clinico Universitario and IOBA (Eye Institute) University of Valladolid, Valladolid, Spain

    José Carlos Pastor

  13. Department of Ophthalmology, University of Crete, Crete, Greece

    Miltiadis Tsilimbaris

  14. Department of Ophthalmology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Douglas Rhee

  15. Institute of Experimental Ophthalmology, Westfalian Wilhelms-University of Münster, Albert-Schweitzer Campus 1, Münster, D15, 48149, Germany

    Solon Thanos

  16. Department of Ophthalmology, Kagoshima University, Kagoshima, Japan

    Taiji Sakamoto

  17. Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA

    Scott R. Lambert

Authors
  1. Demetrios G. Vavvas
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  2. Thaddeus P. Dryja
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  3. M. Edward Wilson
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  4. Timothy W. Olsen
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  5. Ankoor Shah
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  6. Ula Jurkunas
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  7. Roberto Pineda
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  9. Sotiria Palioura
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  10. Peter Veldman
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  11. Javier Moreno-Montañés
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  12. Maria D. Pinazo-Duran
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  13. José Carlos Pastor
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  14. Miltiadis Tsilimbaris
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  15. Douglas Rhee
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  16. Kathryn Colby
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  17. David G. Hunter
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  18. Solon Thanos
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  19. Taiji Sakamoto
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  20. Louis R. Pasquale
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  21. Joan W. Miller
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  22. Deborah VanderVeen
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  23. Scott R. Lambert
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Contributions

D.G.V., T.P.D., M.E.W., T.W.O., L.R.P., J.W.M., D.V. and S.R.L. conceived, wrote and edited the manuscript. A.S., U.J., R.P., V.P., S.P., P.V., J.M.-M., M.D.P.-D., J.C.P., M.T., D.R., K.C., D.G.H., S.T. and T.S. reviewed and edited the manuscript.

Corresponding authors

Correspondence to Demetrios G. Vavvas, M. Edward Wilson, Timothy W. Olsen, José Carlos Pastor, Louis R. Pasquale, Joan W. Miller, Deborah VanderVeen or Scott R. Lambert.

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The authors declare no competing financial interests.

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Vavvas, D., Dryja, T., Wilson, M. et al. Lens regeneration in children. Nature 556, E2–E3 (2018). https://doi.org/10.1038/nature26149

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