Extended Data Figure 5 : Hypothesis test enumeration and enrichment for mutations in highly conserved fetal brain-active enhancers.

From: De novo mutations in regulatory elements in neurodevelopmental disorders

Extended Data Figure 5

a, We corrected for thirteen tests in order to account for the nested hypotheses based on element class and phenotype in this analysis. b, Evolutionarily conserved fetal brain-active enhancers (n = 106) are enriched for DNMs in exome-negative probands.