a, Survival of mice after i.v. infection with 10⁶ A. fumigatus conidia (n = 16 mice per group). Pooled data from two independent experiments, analysed by log-rank test. b, c, Tissue fungal burdens (b) and brain cytokine levels (c) of mice four days after i.v. infection with 10⁶ A. fumigatus conidia (n = 12 mice per group). CFU, colony-forming unit. Values shown are mean ± s.e.m. of pooled data from two independent experiments, analysed by two-sided Mann–Whitney U test. Green circles indicate individual data points in all cases. d, Survival of mice after i.v. infection with 10⁶ ΔpksP A. fumigatus conidia (n = 15 mice per group). Pooled data from two independent experiments, analysed by log-rank test. e, Cumulative incidence analysis of invasive aspergillosis after transplantation according to donor (wild-type, n = 238 individuals; SNP allele, n = 72 individuals) or recipient (wild-type, n = 228 individuals; SNP allele, n = 80 individuals) CLEC1A rs2306894 genotypes, analysed by two-sided Gray’s test. f, Cytokine production in monocyte-derived macrophages, after stimulation with A. fumigatus conidia (wild-type, n = 14 individuals; SNP allele, n = 5 individuals). Values shown are mean ± s.d., analysed by two-sided Mann–Whitney U test. *P ≤ 0.05; NS, not significant; HR, hazard ratio.