a, Representative histograms showing the presence or absence of human MelLec ligands on ΔrodA or ΔrodAΔpksP A. fumigatus conidia, as determined by flow cytometry. Fc-CLEC12B was used as a control (Fc-control). The experiment was repeated at least three times independently, with similar results. b, Survival of irradiated wild-type mice reconstituted with wild-type or Clec1a^−/− bone marrow (BM), as indicated, after i.v. infection with 10⁶ A. fumigatus conidia (n = 16 mice per group). Pooled data from two independent experiments, analysed by log-rank test. c, Inflammatory cytokine production in monocyte-derived macrophages isolated from genotyped individuals, after stimulation with lipopolysaccharide (wild-type n = 14 individuals, SNP allele n = 5 individuals). Values shown are mean ± s.d., analysed by two-sided Mann–Whitney U test. d, Inflammatory cytokine production in peripheral blood mononuclear cells isolated from genotyped Dutch individuals, after stimulation with heat-killed A. fumigatus conidia (wild-type n = 72 individuals, SNP allele n = 17 individuals). Boxes represent the median values and interquartile ranges; whiskers represent minimum and maximum values, analysed by two-sided Mann–Whitney U test. e, Inflammatory cytokine production in transduced RAW264.7 macrophages expressing wild-type or SNP allele after stimulation with ΔrodA or ΔrodAΔpksP A. fumigatus conidia, as indicated. Values shown are mean ± s.d., analysed by one-way ANOVA and repeated at least three times independently, with similar results. *P ≤ 0.05; NS, not significant.