Extended Data Figure 9 : Validation of ependymoma transcription factors.

From: Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Extended Data Figure 9

a, b, Gene expression of ‘high activity’ transcription factors (ranked <50) (a) and ‘low activity’ transcription factors (ranked >50) (b) in ependymoma (n = 83 independent samples) versus normal brain tissue (n = 172 independent samples). Box plots showing median value (horizontal bar), interquartile range and dotted line representing the data range. Comparison between groups was assessed using a two-sided Wilcoxon rank-sum test. c, Constituent enhancer activity in the central nervous system (CNS) of developing zebrafish embryos derived from subgroup-specific super enhancers identified in ependymomas.