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Cell biology

Bulky tether proteins aid membrane fusion

Nature volume 551, pages 576–577 (2017)Cite this article

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The energy source that drives vesicle fusion with a target organelle in vivo has been unclear. It emerges that proteins that tether fusing structures together also decrease the energy needed for the final fusion step. See Letter p.634

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Figure 1: Bulky proteins aid the membrane-fusion process.

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References

  1. D'Agostino, M., Risselada, H. J., Lürick, A., Ungermann, C. & Mayer, A. Nature 551, 634–638 (2017).

    Article  ADS  CAS  Google Scholar 

  2. Dubuke, M. L. & Munson, M. Front. Cell Dev. Biol. 4, 42 (2016).

    Article  Google Scholar 

  3. Witkowska, A. & Jahn, R. Biophys. J. 113, 1251–1259 (2017).

    Article  ADS  CAS  Google Scholar 

  4. Solinger, J. A. & Spang, A. FEBS J. 280, 2743–2757 (2013).

    Article  CAS  Google Scholar 

  5. Montecucco, C., Schiavo, G. & Pantano, S. Trends Biochem. Sci. 30, 367–372 (2005).

    Article  CAS  Google Scholar 

  6. van den Bogaart, G. et al. Nature Struct. Mol. Biol. 17, 358–364 (2010).

    Article  CAS  Google Scholar 

  7. Wu, Z. et al. eLife 6, e22964 (2017).

    Article  Google Scholar 

  8. Fang, Q. & Lindau, M. Physiology 29, 278–285 (2014).

    Article  CAS  Google Scholar 

  9. Spang, A. Traffic 13, 908–913 (2012).

    Article  CAS  Google Scholar 

  10. Schindler, C. & Spang, A. Mol. Biol. Cell 18, 2852–2863 (2007).

    Article  CAS  Google Scholar 

  11. Song, H., Orr, A., Duan, M., Merz, A. J. & Wickner, W. eLife 6, e26646 (2017).

    Article  Google Scholar 

  12. Schwartz, M. L. et al. eLife 6, e27396 (2017).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Biozentrum, University of Basel, Basel, 4056, Switzerland

    Anne Spang

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  1. Anne Spang
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Correspondence to Anne Spang.

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Spang, A. Bulky tether proteins aid membrane fusion. Nature 551, 576–577 (2017). https://doi.org/10.1038/nature24754

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