Re-evaluating evolution in the HIV reservoir

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Figure 1: For the first six months of ART, the persistent latent reservoir makes up a minority of sampled sequences.
Figure 2: Simulated decay of labile infected cell population creates misleading appearance of viral replication and evolution in first six months of treatment.

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Authors

Contributions

Wrote the manuscript: D.I.S.R., A.L.H., S.B.L., R.F.S. Simulations and phylogenetic analyses: D.I.S.R., A.L.H., R.F.S. Estimation of labile compartments: S.B.L., R.F.S.

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Correspondence to Robert F. Siliciano.

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The authors declare no competing financial interests.

Extended data figures and tables

Extended Data Table 1 Analysis of post-treatment simulated samples based on sequences obtained before treatment14

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This file contains Supplementary Table 1. (XLSX 63 kb)

Supplementary Data

This file contains Supplementary Table 2. (XLSX 3036 kb)

Supplementary Data

This file contains Supplementary Table 3. (XLSX 100 kb)

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Rosenbloom, D., Hill, A., Laskey, S. et al. Re-evaluating evolution in the HIV reservoir. Nature 551, E6–E9 (2017). https://doi.org/10.1038/nature24634

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