Extended Data Figure 3 : Electron density for FT827 and FT671.

From: Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Extended Data Figure 3

ac, Stereo representation of 2|Fo| − |Fc| electron density maps, contoured at 1σ, covering all atoms of the inhibitors in each of the two independent USP7 molecules of the asymmetric unit. Protein is shown as in Fig. 2a, and compound carbon atoms are in yellow. a, FT671; b, FT827; c, FT827, in an orientation to show the covalent linkage between inhibitor and Cys223.