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Shrinking maps of RNA modifications

The presence of N1 methyl groups on adenine bases was thought to be widespread in messenger RNAs. It now seems that these modifications are much less prevalent, and occur on mRNAs that structurally mimic transfer RNA. See Letter p.251

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Figure 1: Mimicry of non-coding RNA structures by messenger RNA directs nucleotide modification.


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  1. Dominissini, D. et al. Nature 530, 441–446 (2016).

    Article  ADS  CAS  Google Scholar 

  2. Li, X. et al. Nature Chem. Biol. 12, 311–316 (2016).

    Article  ADS  CAS  Google Scholar 

  3. Safra, M. et al. Nature 551, 251–255 (2017).

    Article  ADS  CAS  Google Scholar 

  4. Simms, C. L., Hudson, B. H., Mosior, J. W., Rangwala, A. S. & Zaher, H. S. Cell Rep. 9, 1256–1264 (2014).

    Article  CAS  Google Scholar 

  5. Helm, M. et al. Nucleic Acids Res. 26, 1636–1643 (1998).

    Article  CAS  Google Scholar 

  6. Sprinzl, M., Horn, C., Brown, M., Ioudovitch, A. & Steinberg, S. Nucleic Acids Res. 26, 148–153 (1998).

    Article  CAS  Google Scholar 

  7. Schwartz, S. et al. Cell 159, 148–162 (2014).

    Article  CAS  Google Scholar 

  8. Pendleton, K. E. et al. Cell 169, 824–835 (2017).

    Article  CAS  Google Scholar 

  9. Schwartz, S. et al. Cell 155, 1409–1421 (2013).

    Article  CAS  Google Scholar 

  10. Meyer, K. D. et al. Cell 149, 1635–1646 (2012).

    Article  CAS  Google Scholar 

  11. Carlile, T. M. et al. Nature 515, 143–146 (2014).

    Article  ADS  CAS  Google Scholar 

  12. Dai, Q. et al. Nature Methods 14, 695–698 (2017).

    Article  CAS  Google Scholar 

  13. Gillen, A. E., Yamamoto, T. M., Kline, E., Hesselberth, J. R. & Kabos, P. BMC Genom. 17, 338 (2016).

    Article  Google Scholar 

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Correspondence to Samie R. Jaffrey.

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Grozhik, A., Jaffrey, S. Shrinking maps of RNA modifications. Nature 551, 174–176 (2017).

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