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Epitranscriptomics

Shrinking maps of RNA modifications

The presence of N1 methyl groups on adenine bases was thought to be widespread in messenger RNAs. It now seems that these modifications are much less prevalent, and occur on mRNAs that structurally mimic transfer RNA. See Letter p.251

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Figure 1: Mimicry of non-coding RNA structures by messenger RNA directs nucleotide modification.

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Correspondence to Samie R. Jaffrey.

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Grozhik, A., Jaffrey, S. Shrinking maps of RNA modifications. Nature 551, 174–176 (2017). https://doi.org/10.1038/nature24156

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