Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Complex assistance for DNA invasion

Repair of broken DNA is vital for genome stability and to prevent the development of cancer. Research shows how the tumour-suppressor protein BRCA1 promotes a DNA-repair pathway called homologous recombination. See Article p.360

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Roles of the BRCA1 and BRCA2 tumour-suppressor proteins in homologous recombination.


  1. Kowalczykowski, S. C. Cold Spring Harb. Perspect. Biol. 7, a016410 (2015).

    Article  Google Scholar 

  2. Zhao, W. et al. Nature 550, 360–365 (2017).

    Article  ADS  CAS  Google Scholar 

  3. Prakash, R., Zhang, Y., Feng, W. & Jasin, M. Cold Spring Harb. Perspect. Biol. 7, a016600 (2015).

    Article  Google Scholar 

  4. Jeggo, P. A. & Löbrich, M. Biochem. J. 471, 1–11 (2015).

    Article  CAS  Google Scholar 

  5. Jensen, R. B., Carreira, A. & Kowalczykowski, S. C. Nature 467, 678–683 (2010).

    Article  ADS  CAS  Google Scholar 

  6. Bunting, S. F. et al. Cell 141, 243–254 (2010).

    Article  CAS  Google Scholar 

  7. Paull, T. T., Cortez, D., Bowers, B., Elledge, S. J. & Gellert, M. Proc. Natl Acad. Sci. USA 98, 6086–6091 (2001).

    Article  ADS  CAS  Google Scholar 

  8. Simons, A. M. et al. Cancer Res. 66, 2012–2018 (2006).

    Article  CAS  Google Scholar 

  9. Thorslund, T. et al. Nature Struct. Mol. Biol. 17, 1263–1265 (2010).

    Article  CAS  Google Scholar 

  10. Liu, J., Doty, T., Gibson, B. & Heyer, W.-D. Nature Struct. Mol. Biol. 17, 1260–1262 (2010).

    Article  CAS  Google Scholar 

  11. Taylor, M. R. G. et al. Cell 162, 271–286 (2015).

    Article  CAS  Google Scholar 

  12. Sigurdsson, S. et al. Genes Dev. 15, 3308–3318 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Petr Cejka.

Related links

Related links

Related links in Nature Research

DNA repair: A unifying mechanism in neurodegeneration

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cejka, P. Complex assistance for DNA invasion. Nature 550, 342–343 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer