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Obesity

Receptors identified for a weight regulator

The discovery of the receptors for the protein GDF15 suggests that it regulates food uptake through the emergency pathway — a neuronal circuit that causes weight loss in response to cancer, tissue damage and stress. See Letter p.255

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Figure 1: An expanded role for RET-dependent signalling.

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Correspondence to Mart Saarma or Adrian Goldman.

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Saarma, M., Goldman, A. Receptors identified for a weight regulator. Nature 550, 195–197 (2017). https://doi.org/10.1038/nature24143

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