Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Obesity

Receptors identified for a weight regulator

The discovery of the receptors for the protein GDF15 suggests that it regulates food uptake through the emergency pathway — a neuronal circuit that causes weight loss in response to cancer, tissue damage and stress. See Letter p.255

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: An expanded role for RET-dependent signalling.

Notes

  1. See all news & views

References

  1. Hsu, J.-Y. et al. Nature 550, 255–259 (2017)

    Article  ADS  Google Scholar 

  2. Emmerson, P. J. et al. Nature Med. http://dx.doi.org/10.1038/nm.4393 (2017).

  3. Mullican, S. E. et al. Nature Med. http://dx.doi.org/10.1038/nm.4392 (2017)

  4. Yang, L. et al. Nature Med. http://dx.doi.org/10.1038/nm.4394 (2017).

  5. Unsicker, K., Spittau, B. & Krieglstein, K. Cytokine Growth Factor Rev. 24, 373–384 (2013).

    Article  CAS  Google Scholar 

  6. Macia, L. et al. PLoS ONE 7, e34868 (2012).

    Article  CAS  ADS  Google Scholar 

  7. Johnen, H. et al. Nature Med. 13, 1333–1340 (2007).

    Article  CAS  Google Scholar 

  8. Tsai, V. W.-W. et al. PLoS ONE 27, e100370 (2014).

    Article  Google Scholar 

  9. Airaksinen, M. S. & Saarma, M. Nature Rev. Neurosci. 3, 383–394 (2002).

    Article  CAS  Google Scholar 

  10. Li, Z. et al. J. Neurochem. 95, 361–376 (2005).

    Article  CAS  Google Scholar 

  11. Kramer, E. R. et al. PLoS Biol. 5, e39 (2007).

    Article  Google Scholar 

  12. Kopra, J. et al. Nature Neurosci. 18, 319–322 (2015).

    Article  CAS  Google Scholar 

  13. Prakash, V. et al. J. Biol. Chem. 283, 35164–35172 (2008).

    Article  Google Scholar 

  14. Carter, M. E., Soden, M. E., Zweifel, L. S. & Palmiter, R. D. Nature 503, 111–114 (2013).

    Article  CAS  ADS  Google Scholar 

  15. Morton, G. J., Meek, M. H. & Schwartz, M. W. Nature Rev. Neurosci. 15, 367–378 (2014).

    Article  CAS  Google Scholar 

  16. Strelau, J. et al. J. Neurosci. 20, 8597–8603 (2000).

    Article  CAS  Google Scholar 

  17. Strelau, J. et al. J. Neurosci. 29, 13640–13648 (2009).

    Article  CAS  Google Scholar 

  18. Sidorova, Y. A. Front Pharmacol. 8, 365 (2017).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Mart Saarma or Adrian Goldman.

Related links

Related links

Related links in Nature Research

Neuroscience: Weight loss through smoking

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Saarma, M., Goldman, A. Receptors identified for a weight regulator. Nature 550, 195–197 (2017). https://doi.org/10.1038/nature24143

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature24143

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing