a, Representative confocal images (Ki67, green; human nuclear antigen, red; MBP, white) of vehicle-treated or ADAM10i-treated mice bearing frontal cortex SU-pcGBM2 xenografts; images similar to but lower magnification than those shown in Fig. 4e; n = 4 vehicle, n = 4 ADAM10i-treated mice. Scale bar, 100 μm. b, Brain tissue and plasma levels of XL-784 at various time points following a single 50 mg kg−1 intraperitoneal dose in NSG mice as assessed by LC–MS/MS. n = 3 mice at each data point. Data are mean ± s.d.