Figure 2 : Modelling the 4D Nucleome.

From: The 4D nucleome project

Figure 2

Data obtained with imaging and chromosome conformation capture-based assays can be used for building spatial and dynamic models of chromosomes using two main approaches. In the data-driven approach, experimental data are used directly to generate ensembles of conformations that reproduce the experimental observations. In the de novo approach, ensembles of conformations are built according to known or hypothesized physical or biological processes. Models are then selected based on their agreement with experimental data.