Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Leukaemia

Vitamin C regulates stem cells and cancer

It emerges that high levels of vitamin C in blood-forming stem cells influence the number and function of the cells and affect the development of leukaemia, through binding to a tumour-suppressor protein, Tet2. See Article p.476

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The effects of vitamin C on stem-cell biology and leukaemia.

Notes

  1. 1.

    See all news & views

References

  1. 1

    Dang, L. et al. Nature 462, 739–744 (2009).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Mihaylova, M. M., Sabatini, D. M. & Yilmaz, O. H. Cell Stem Cell 14, 292–305 (2014).

    CAS  Article  Google Scholar 

  3. 3

    Agathocleous, M. et al. Nature 549, 476–481 (2017).

    ADS  Article  Google Scholar 

  4. 4

    Cimmino, L. et al. Cell http://dx.doi.org/10.1016/j.cell.2017.07.032 (2017).

  5. 5

    Oguro, H., Ding, L. & Morrison, S. J. Cell Stem Cell 13, 102–116 (2013).

    CAS  Article  Google Scholar 

  6. 6

    Yin, R. et al. J. Am. Chem. Soc. 135, 10396–10403 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Tahiliani, M. et al. Science 324, 930–935 (2009).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Moran-Crusio, K. et al. Cancer Cell 20, 11–24 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Delhommeau, F. et al. N. Engl. J. Med. 360, 2289–2301 (2009).

    Article  Google Scholar 

  10. 10

    Patel, J. P. et al. N. Engl. J. Med. 366, 1079–1089 (2012).

    CAS  Article  Google Scholar 

  11. 11

    Loria, C. M., Klag, M. J., Caulfield, L. E. & Whelton, P. K. Am. J. Clin. Nutr. 72, 139–145 (2000).

    CAS  Article  Google Scholar 

  12. 12

    Moser, M. A. & Chun, O. K. Int. J. Mol. Sci. 17, 1328 (2016).

    Article  Google Scholar 

  13. 13

    Lee, B., Oh, S. W. & Myung, S. K. Korean J. Fam. Med. 36, 278–285 (2015).

    Article  Google Scholar 

  14. 14

    Schleicher, R. L., Carroll, M. D., Ford, E. S. & Lacher, D. A. Am. J. Clin. Nutr. 90, 1252–1263 (2009).

    CAS  Article  Google Scholar 

  15. 15

    Adams, P. D., Jasper, H. & Rudolph, K. L. Cell Stem Cell 16, 601–612 (2015).

    CAS  Article  Google Scholar 

  16. 16

    Sattar, N. et al. PLoS Med. 6, e1000099 (2009).

    Article  Google Scholar 

  17. 17

    Jaiswal, S. et al. N. Engl. J. Med. 371, 2488–2498 (2014).

    Article  Google Scholar 

  18. 18

    Jaiswal, S. et al. N. Engl. J. Med. 377, 111–121 (2017).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Benjamin L. Ebert.

Related links

Related links

Related links in Nature Research

Stem cells: Valine starvation leads to a hungry niche

Cancer therapy: The leukaemia epigenome targeted

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Miller, P., Ebert, B. Vitamin C regulates stem cells and cancer. Nature 549, 462–464 (2017). https://doi.org/10.1038/nature23548

Download citation

Further reading

  • Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans

    • Eevi Kaasinen
    • , Outi Kuismin
    • , Kristiina Rajamäki
    • , Heikki Ristolainen
    • , Mervi Aavikko
    • , Johanna Kondelin
    • , Silva Saarinen
    • , Davide G. Berta
    • , Riku Katainen
    • , Elina A. M. Hirvonen
    • , Auli Karhu
    • , Aurora Taira
    • , Tomas Tanskanen
    • , Amjad Alkodsi
    • , Minna Taipale
    • , Ekaterina Morgunova
    • , Kaarle Franssila
    • , Rainer Lehtonen
    • , Markus Mäkinen
    • , Kristiina Aittomäki
    • , Aarno Palotie
    • , Mitja I. Kurki
    • , Olli Pietiläinen
    • , Morgane Hilpert
    • , Elmo Saarentaus
    • , Jaakko Niinimäki
    • , Juhani Junttila
    • , Kari Kaikkonen
    • , Pia Vahteristo
    • , Radek C. Skoda
    • , Mikko R. J. Seppänen
    • , Kari K. Eklund
    • , Jussi Taipale
    • , Outi Kilpivaara
    •  & Lauri A. Aaltonen

    Nature Communications (2019)

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing