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Leukaemia

Vitamin C regulates stem cells and cancer

Nature volume 549, pages 462–464 (2017)Cite this article

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It emerges that high levels of vitamin C in blood-forming stem cells influence the number and function of the cells and affect the development of leukaemia, through binding to a tumour-suppressor protein, Tet2. See Article p.476

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Figure 1: The effects of vitamin C on stem-cell biology and leukaemia.

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References

  1. Dang, L. et al. Nature 462, 739–744 (2009).

    Article  ADS  CAS  Google Scholar 

  2. Mihaylova, M. M., Sabatini, D. M. & Yilmaz, O. H. Cell Stem Cell 14, 292–305 (2014).

    Article  CAS  Google Scholar 

  3. Agathocleous, M. et al. Nature 549, 476–481 (2017).

    Article  ADS  Google Scholar 

  4. Cimmino, L. et al. Cell http://dx.doi.org/10.1016/j.cell.2017.07.032 (2017).

  5. Oguro, H., Ding, L. & Morrison, S. J. Cell Stem Cell 13, 102–116 (2013).

    Article  CAS  Google Scholar 

  6. Yin, R. et al. J. Am. Chem. Soc. 135, 10396–10403 (2013).

    Article  CAS  Google Scholar 

  7. Tahiliani, M. et al. Science 324, 930–935 (2009).

    Article  ADS  CAS  Google Scholar 

  8. Moran-Crusio, K. et al. Cancer Cell 20, 11–24 (2011).

    Article  CAS  Google Scholar 

  9. Delhommeau, F. et al. N. Engl. J. Med. 360, 2289–2301 (2009).

    Article  Google Scholar 

  10. Patel, J. P. et al. N. Engl. J. Med. 366, 1079–1089 (2012).

    Article  CAS  Google Scholar 

  11. Loria, C. M., Klag, M. J., Caulfield, L. E. & Whelton, P. K. Am. J. Clin. Nutr. 72, 139–145 (2000).

    Article  CAS  Google Scholar 

  12. Moser, M. A. & Chun, O. K. Int. J. Mol. Sci. 17, 1328 (2016).

    Article  Google Scholar 

  13. Lee, B., Oh, S. W. & Myung, S. K. Korean J. Fam. Med. 36, 278–285 (2015).

    Article  Google Scholar 

  14. Schleicher, R. L., Carroll, M. D., Ford, E. S. & Lacher, D. A. Am. J. Clin. Nutr. 90, 1252–1263 (2009).

    Article  CAS  Google Scholar 

  15. Adams, P. D., Jasper, H. & Rudolph, K. L. Cell Stem Cell 16, 601–612 (2015).

    Article  CAS  Google Scholar 

  16. Sattar, N. et al. PLoS Med. 6, e1000099 (2009).

    Article  Google Scholar 

  17. Jaiswal, S. et al. N. Engl. J. Med. 371, 2488–2498 (2014).

    Article  Google Scholar 

  18. Jaiswal, S. et al. N. Engl. J. Med. 377, 111–121 (2017).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Peter G. Miller & Benjamin L. Ebert

  2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, and at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts

    Peter G. Miller & Benjamin L. Ebert

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  1. Peter G. Miller
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  2. Benjamin L. Ebert
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Correspondence to Benjamin L. Ebert.

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Miller, P., Ebert, B. Vitamin C regulates stem cells and cancer. Nature 549, 462–464 (2017). https://doi.org/10.1038/nature23548

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