Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


From embryo mutation to adult degeneration

Mutations in embryonic blood-cell precursors called erythro-myeloid progenitors cause abnormal activation of their descendants — immune cells called microglia — leading to neurodegeneration in mice. See Letter p.389

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Cell-specific effects of mutations in the BRAF protein.


  1. See all news & views


  1. Palis, J. FEBS Lett. 590, 3965–3974 (2016).

    CAS  Article  Google Scholar 

  2. Schulz, C. et al. Science 336, 86–90 (2012).

    ADS  CAS  Article  Google Scholar 

  3. Gomez Perdiguero, E. et al. Nature 518, 547–551 (2015).

    ADS  Article  Google Scholar 

  4. Epelman, S. et al. Immunity 40, 91–104 (2014).

    CAS  Article  Google Scholar 

  5. Chan, R. J. & Yoder, M. C. Blood 121, 4815–4817 (2013).

    CAS  Article  Google Scholar 

  6. Li, Z. et al. Nature Genet. 37, 613–619 (2005).

    CAS  Article  Google Scholar 

  7. Mass, E. et al. Nature 549, 389–393 (2017).

    ADS  CAS  Article  Google Scholar 

  8. Emile, J.-F. et al. Blood 127, 2672–2681 (2016).

    CAS  Article  Google Scholar 

  9. Tiacci, E. et al. N. Engl. J. Med. 364, 2305–2315 (2011).

    CAS  Article  Google Scholar 

  10. Trifa, A. P. et al. Leuk. Lymphoma 53, 2496–2497 (2012).

    CAS  Article  Google Scholar 

  11. Idbaih, A. et al. Neurology 83, 1478–1480 (2014).

    Article  Google Scholar 

  12. Hyman, D. M. et al. N. Engl. J. Med. 373, 726–736 (2015).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Mervin C. Yoder.

Related links

Related links

Related links in Nature Research

Microbiology: Gut microbes augment neurodegeneration

Stem cells: Blood lines from embryo to adult

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tarnawsky, S., Yoder, M. From embryo mutation to adult degeneration. Nature 549, 340–342 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing