Mutations in embryonic blood-cell precursors called erythro-myeloid progenitors cause abnormal activation of their descendants — immune cells called microglia — leading to neurodegeneration in mice. See Letter p.389
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Tarnawsky, S., Yoder, M. From embryo mutation to adult degeneration. Nature 549, 340–342 (2017). https://doi.org/10.1038/nature23547
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DOI: https://doi.org/10.1038/nature23547