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Neuroscience

From embryo mutation to adult degeneration

Mutations in embryonic blood-cell precursors called erythro-myeloid progenitors cause abnormal activation of their descendants — immune cells called microglia — leading to neurodegeneration in mice. See Letter p.389

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Figure 1: Cell-specific effects of mutations in the BRAF protein.

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Correspondence to Mervin C. Yoder.

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Tarnawsky, S., Yoder, M. From embryo mutation to adult degeneration. Nature 549, 340–342 (2017). https://doi.org/10.1038/nature23547

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