Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Heart disease

Putative medicines that mimic mutations

Molecules that block the activity or production of the protein ANGPTL3 have now been found to lower blood levels of lipoproteins and cholesterol in mice and healthy humans, mimicking the protective effects of genetic mutations in ANGPTL3.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Triglyceride-rich lipoproteins and the risk of heart attack.


  1. See all news & views


  1. Stone, N. J. et al. Circulation 129, S1–S45 (2014).

    Article  Google Scholar 

  2. Dewey, F. E. et al. N. Engl. J. Med. 377, 211–221 (2017).

    Article  CAS  Google Scholar 

  3. Graham, M. J. et al. N. Engl. J. Med. 377, 222–232 (2017).

    Article  CAS  Google Scholar 

  4. Musunuru, K. & Kathiresan, S. Circ. Res. 118, 579–585 (2016).

    Article  CAS  Google Scholar 

  5. Goldstein, J. L. & Brown, M. S. Cell 161, 161–172 (2015).

    Article  CAS  Google Scholar 

  6. Harper, A. R., Nayee, S. & Topol, E. J. Nature Rev. Genet. 16, 689–701 (2015).

    Article  CAS  Google Scholar 

  7. Abifadel, M. et al. Nature Genet. 34, 154–156 (2003).

    Article  CAS  Google Scholar 

  8. Cohen, J. C., Boerwinkle, E., Mosley, T. H. Jr & Hobbs, H. H. N. Engl. J. Med. 354, 1264–1272 (2006).

    Article  CAS  Google Scholar 

  9. Zhao, Z. et al. Am. J. Hum. Genet. 79, 514–523 (2006).

    Article  CAS  Google Scholar 

  10. Sabatine, M. S. et al. N. Engl. J. Med. 376, 1713–1722 (2017).

    Article  CAS  Google Scholar 

  11. Koishi, R. et al. Nature Genet. 30, 151–157 (2002).

    Article  CAS  Google Scholar 

  12. Shimizugawa, T. et al. J. Biol. Chem. 277, 33742–33748 (2002).

    Article  CAS  Google Scholar 

  13. Musunuru, K. et al. N. Engl. J. Med. 363, 2220–2227 (2010).

    Article  CAS  Google Scholar 

  14. Stitziel, N. O. et al. J. Am. Coll. Cardiol. 69, 2054–2063 (2017).

    Article  CAS  Google Scholar 

  15. Khera, A. V. & Kathiresan, S. Nature Rev. Genet. 18, 331–344 (2017).

    Article  CAS  Google Scholar 

  16. Kazi, D. S. et al. J. Am. Med. Assoc. 316, 743–753 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Sekar Kathiresan.

Related links

Related links

Related links in Nature Research

Regenerative biology: Take the brakes off for liver repair

Cardiology: Bad matters made worse

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kathiresan, S. Putative medicines that mimic mutations. Nature 548, 530–531 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing