Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


A bitter–sweet symphony

Information about taste sensations, such as bitter or sweet, is relayed from the mouse tongue to the brain through taste-specific pathways. It emerges that semaphorin proteins guide the wiring of these pathways. See Letter p.330

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Wiring the taste system in mice.


  1. See all news & views


  1. Lee, H., Macpherson, L. J., Parada, C. A., Zuker, C. S. & Ryba, N. J. P. Nature 548, 330–333 (2017).

    Article  ADS  CAS  Google Scholar 

  2. Yarmolinsky, D. A., Zuker, C. S. & Ryba, N. J. P. Cell 139, 234–244 (2009).

    Article  CAS  Google Scholar 

  3. Barretto, R. P. J. et al. Nature 517, 373–376 (2015).

    Article  ADS  CAS  Google Scholar 

  4. Kruger, R. P., Aurandt, J. & Guan, K.-L. Nature Rev. Mol. Cell Biol. 6, 789–800 (2005).

    Article  CAS  Google Scholar 

  5. Zhang, K. X., Tan, L., Pellegrini, M., Zipursky, S. L. & McEwen, J. M. Cell Rep. 14, 1258–1271 (2016).

    Article  CAS  Google Scholar 

  6. Li, H. et al. Preprint at (2017).

  7. Kolodkin, A. L. & Tessier-Lavigne, M. Cold Spring Harb. Perspect. Biol. 3, a001727 (2011).

    Article  Google Scholar 

  8. Zipursky, S. L. & Sanes, J. R. Cell 143, 343–353 (2010).

    Article  CAS  Google Scholar 

  9. Hong, W. & Luo, L. Genetics 196, 17–29 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Liqun Luo.

Related links

Related links

Related links in Nature Research

Neurobiology: The good taste of genomics

Neurobiology: Tepid tastes

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, J., Luo, L. A bitter–sweet symphony. Nature 548, 285–287 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing