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Role of stem-cell divisions in cancer risk

Nature volume 548, pages E13E14 (10 August 2017) | Download Citation

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References

  1. 1.

    & Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347, 78–81 (2015)

  2. 2.

    & Musings on the theory that variation in cancer risk among tissues is explained by the number of divisions of the normal stem cells. Preprint at (2015)

  3. 3.

    & Cancer risk: role of environment—response. Science 347, 729–731 (2015)

  4. 4.

    ., ., & Substantial contribution of extrinsic risk factors to cancer development. Nature 529, 43–47 (2016)

  5. 5.

    et al. Contribution of screening and survival differences to racial disparities in colorectal cancer rates. Cancer Epidemiol. Biomarkers Prev. 21, 728–736 (2012)

  6. 6.

    & Increasing incidence of thyroid cancer in the United States, 1973-2002. J. Am. Med. Assoc. 295, 2164–2167 (2006)

  7. 7.

    et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116, 544–573 (2010)

  8. 8.

    , & Non-Hodgkin’s lymphoma. Cancer 75 (Suppl.), 370–380 (1995)

  9. 9.

    , & The decline in U.S. cancer mortality in people born since 1925. Cancer Res. 69, 6500–6505 (2009)

  10. 10.

    et al. Signatures of mutational processes in human cancer. Nature 500, 415–421 (2013)

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Author information

Affiliations

  1. Division of Biostatistics and Bioinformatics, Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 550 North Broadway, Baltimore, Maryland 21205, USA

    • Cristian Tomasetti
  2. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA

    • Cristian Tomasetti
  3. Department of Mathematics, Duke University, Durham, North Carolina 27708, USA

    • Rick Durrett
  4. Department of Statistics, Rice University, Houston, Texas 77005, USA

    • Marek Kimmel
  5. Laboratoire de Probabilités & Modéles Aléatoires, UMPC Université Paris 06, 75252 Paris, France

    • Amaury Lambert
    •  & Giovanni Parmigiani
  6. Department of Biostatistics, Harvard T.H. Chan School of Public Health & Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA

    • Giovanni Parmigiani
  7. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10017, USA

    • Ann Zauber
  8. Ludwig Center & Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street St, Baltimore, Maryland 21205, USA

    • Bert Vogelstein

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Contributions

C.T. and B.V. conceived and designed the research. C.T., R.D., M.K., A.L., G.P., A.Z. and B.V. performed related research. C.T. and B.V. wrote the first draft of the article and all authors contributed to the submitted version.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Cristian Tomasetti.

About this article

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DOI

https://doi.org/10.1038/nature23302

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