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Cancer

A precision approach to tumour treatment

Nature volume 548, pages 40–41 (2017)Cite this article

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Progress is being made in the use of personalized approaches to create both in vitro and in vivo tumour models that could be used to aid cancer drug-treatment decisions and increase our understanding of how tumours respond to therapy.

Precision cancer therapy pairs the latest insights into tumour biology with cutting-edge technologies to identify gene alterations that can be directly matched to anti-cancer agents. Writing in Cancer Discovery, Pauli et al.1 outline how they have opened another chapter of this work by using DNA sequencing of tumour samples along with testing of patient-derived cellular models. This enables the use of high-throughput drug screening to assess treatment-response patterns and thereby expand the options for tailoring cancer therapy to the individual.

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Figure 1: Personalized tumour treatment.

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References

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Authors and Affiliations

  1. Vall d'Hebron Institute of Oncology, Barcelona, 08035, Spain

    Rodrigo Dienstmann

  2. Sage Bionetworks, Seattle, USA

    Rodrigo Dienstmann

  3. Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, 08035, Spain

    Josep Tabernero

Authors
  1. Rodrigo Dienstmann
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  2. Josep Tabernero
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Corresponding authors

Correspondence to Rodrigo Dienstmann or Josep Tabernero.

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Dienstmann, R., Tabernero, J. A precision approach to tumour treatment. Nature 548, 40–41 (2017). https://doi.org/10.1038/nature23101

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