Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Energy sensing through a sugar diphosphate

The molecule fructose-1,6-bisphosphate, which is produced during glucose metabolism, has been shown to mediate cellular sensing of glucose deprivation through an unexpected mechanism. See Letter p.112

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Activating AMPK.


  1. See all news & views


  1. Zhang, C.-S. Nature 548, 112–116 (2017).

    Article  ADS  CAS  Google Scholar 

  2. Pasteur, L. C. R. Acad. Sci. 45, 913–916 (1857).

    Google Scholar 

  3. Harden, A. & Young, W. T. Proc. R. Soc. Lond. B 80, 299–311 (1908).

    Article  ADS  CAS  Google Scholar 

  4. Halton, B. Chem. New Zealand 78, 169–173 (2014).

    Google Scholar 

  5. Levene, P. A. & Raymond, A. L. J. Biol. Chem. 80, 633–638 (1928).

    CAS  Google Scholar 

  6. Korman, E. F. Mol. Cell. Biochem. 5, 65–68 (1974).

    Article  CAS  Google Scholar 

  7. Atkinson, D. E. Biochemistry 7, 4030–4034 (1968).

    Article  CAS  Google Scholar 

  8. Passonneau, J. V. & Lowry, O. H. Biochem. Biophys. Res. Commun. 7, 10–15 (1962).

    Article  CAS  Google Scholar 

  9. Oakhill, J. S., Scott, J. W. & Kemp, B. E. Trends Endocrinol. Metab. 23, 125–132 (2012).

    Article  CAS  Google Scholar 

  10. Zhang, C. S. et al. Cell Metab. 20, 526–540 (2014).

    Article  CAS  Google Scholar 

  11. Carroll, B. & Dunlop, E. A. Biochem. J. 474, 1453–1466 (2017).

    Article  CAS  Google Scholar 

  12. Lu, M., Holliday, L. S., Zhang, L., Dunn, W. A. Jr & Gluck, S. L. J. Biol. Chem. 276, 30407–30413 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Bruce E. Kemp.

Related links

Related links

Related links in Nature Research

Signal transduction: How cells sense energy

Cell biology: Form follows function for mitochondria

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kemp, B., Oakhill, J. Energy sensing through a sugar diphosphate. Nature 548, 36–37 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing