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Metabolism

Energy sensing through a sugar diphosphate

Nature volume 548, pages 36–37 (2017)Cite this article

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The molecule fructose-1,6-bisphosphate, which is produced during glucose metabolism, has been shown to mediate cellular sensing of glucose deprivation through an unexpected mechanism. See Letter p.112

On page 112, Zhang et al.1 reveal a previously unknown mechanism by which the enzyme AMP-activated protein kinase (AMPK) is regulated. Why should this discovery matter? Because how your body handles energy supply and demand is a big deal, whether you're an elite athlete or a couch potato. And AMPK is one of the body's master controllers of metabolism.

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Figure 1: Activating AMPK.

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Authors and Affiliations

  1. St Vincent's Institute of Medical Research, Fitzroy, 3065, Victoria, Australia

    Bruce E. Kemp & Jonathan S. Oakhill

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  1. Bruce E. Kemp
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  2. Jonathan S. Oakhill
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Correspondence to Bruce E. Kemp.

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Kemp, B., Oakhill, J. Energy sensing through a sugar diphosphate. Nature 548, 36–37 (2017). https://doi.org/10.1038/nature23099

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