Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunology

Nervous crosstalk to make antibodies

Subjects

Immune cells called T cells help immune-system B cells mature to produce antibodies. This entails signalling between cells using the molecule dopamine — a surprising immunological role for this neurotransmitter. See Article p.318

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Dopamine aids maturation of antibody-producing immune cells.

Notes

  1. See all news & views

References

  1. Papa, I. et al. Nature 547, 318–323 (2017).

    Article  ADS  CAS  Google Scholar 

  2. Crotty, S. Annu. Rev. Immunol. 29, 621–663 (2011).

    Article  CAS  Google Scholar 

  3. Qi, H. Nature Rev. Immunol. 16, 612–625 (2016).

    Article  CAS  Google Scholar 

  4. Victora, G. D. & Nussenzweig, M. C. Annu. Rev. Immunol. 30, 429–457 (2012).

    Article  CAS  Google Scholar 

  5. Fooksman, D. R. et al. Annu. Rev. Immunol. 28, 79–105 (2010).

    Article  CAS  Google Scholar 

  6. Machado, J. D. et al. Cell. Mol. Neurobiol. 30, 1181–1187 (2010).

    Article  CAS  Google Scholar 

  7. Liu, D. et al. Nature 517, 214–218 (2015).

    Article  ADS  CAS  Google Scholar 

  8. Shulman, Z. et al. Science 345, 1058–1062 (2014).

    Article  ADS  CAS  Google Scholar 

  9. Sarkar, C., Basu, B., Chakroborty, D., Dasgupta, P. S. & Basu, S. Brain Behav. Immun. 24, 525–528 (2010).

    Article  CAS  Google Scholar 

  10. Pinoli, M., Marino, F. & Cosentino, M. J. Neuroimmune Pharmacol. http://dx.doi.org/10.1007/s11481-017-9749-2 (2017).

  11. Bhatt-Mehta, V. & Nahata, M. C. Pharmacotherapy 9, 303–314 (1989).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hai Qi.

Related links

Related links

Related links in Nature Research

Cancer: Precision T-cell therapy targets tumours

Immunology: The patterns of T-cell target recognition

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Qi, H. Nervous crosstalk to make antibodies. Nature 547, 288–290 (2017). https://doi.org/10.1038/nature23097

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature23097

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing