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Keeping it real to kill glioblastoma

The results of in vitro and in vivo screens to identify genes that are essential for the survival of a type of brain cancer show almost no overlap, underlining the need for caution when interpreting in vitro studies. See Letter p355.

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Figure 1: Parallel screens for essential genes.


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  1. Ostrom, Q. T. et al. Neuro Oncol. 18, v1–v75 (2016).

    Article  Google Scholar 

  2. Brennan, C. W. et al. Cell 155, 462–477 (2013).

    Article  CAS  Google Scholar 

  3. Cancer Genome Atlas Research Network. Nature 455, 1061–1068 (2008).

  4. Bastien, J. I. L., McNeill, K. A. & Fine, H. A. Cancer 121, 502–516 (2015).

    Article  Google Scholar 

  5. Miller, T. E. et al. Nature 547, 355–359 (2017).

    Article  ADS  CAS  Google Scholar 

  6. Feinberg, A. P., Koldobskiy, M. A. & Göndör, A. Nature Rev. Genet. 17, 284–299 (2016).

    Article  CAS  Google Scholar 

  7. Jones, P. A., Issa, J.-P. J. & Baylin, S. Nature Rev. Genet. 17, 630–641 (2016).

    Article  CAS  Google Scholar 

  8. Liu, X., Kraus, W. L. & Bai, X. Trends Biochem. Sci. 40, 516–525 (2015).

    Article  Google Scholar 

  9. Liu, W. et al. Cell 155, 1581–1595 (2013).

    Article  CAS  Google Scholar 

  10. Possik, P. A. et al. Cell Rep. 9, 1375–1386 (2014).

    Article  CAS  Google Scholar 

  11. Meacham, C. E. et al. Genes Dev. 29, 483–488 (2015).

    Article  CAS  Google Scholar 

  12. Wadhwa, E. & Nicolaides, T. Cureus 8, e620 (2016).

    PubMed  PubMed Central  Google Scholar 

  13. Chaidos, A., Caputo, V. & Karadimitris, A. Ther. Adv. Hematol. 6, 128–141 (2015).

    Article  CAS  Google Scholar 

  14. Cheng, Z. et al. Clin. Cancer Res. 19, 1748–1759 (2013).

    Article  CAS  Google Scholar 

  15. Berenguer-Daizé, C. et al. Int. J. Cancer 139, 2047–2055 (2016).

    Article  Google Scholar 

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Correspondence to Paul A. Northcott.

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Northcott, P. Keeping it real to kill glioblastoma. Nature 547, 291–292 (2017).

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