Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Taming tangled tau

The protein tau forms abnormal filamentous aggregates called tangles in the brains of people with neurodegeneration. Structures of two such filaments offer pathways to a deeper understanding of Alzheimer's disease. See Article p.185

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Structures of tau protein filaments.


  1. See all news & views


  1. Lee, V. M., Goedert, M. & Trojanowski, J. Q. Annu. Rev. Neurosci. 24, 1121–1159 (2001).

    CAS  Article  Google Scholar 

  2. Goedert, M., Eisenberg, D. S. & Crowther, R. A. Annu. Rev. Neurosci. (in the press).

  3. Fitzpatrick, A. W. P. et al. Nature 547, 185–190 (2017).

    ADS  CAS  Article  Google Scholar 

  4. Ayers, J. I., Giasson, B. I. & Borchelt, D. R. Biol. Psychiatry (2017).

  5. Bai, X. C., McMullan, G. & Scheres, S. H. W. Trends Biochem. Sci. 40, 49–57 (2015).

    CAS  Article  Google Scholar 

  6. Crowther, R. A. Proc. Natl Acad. Sci. USA 88, 2288–2292 (1991).

    ADS  CAS  Article  Google Scholar 

  7. Eisenberg, D. S. & Sawaya, M. R. Annu. Rev. Biochem. (2017).

  8. Shi, D., Nannenga, B. L., Iadanza, M. G. & Gonen, T. eLife 2, e01345 (2013).

    Article  Google Scholar 

  9. Rodriguez, J. A. et al. Nature 525, 486–490 (2015).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to David S. Eisenberg or Michael R. Sawaya.

Ethics declarations

Competing interests

D.S.E. declares competing financial interests. See for details.

Related links

Related links

Related links in Nature Research

Alzheimer's disease: Structure of aggregates revealed

Parkinson's disease: Crystals of a toxic core

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Eisenberg, D., Sawaya, M. Taming tangled tau. Nature 547, 170–171 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing